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Thursday, December 10, 2009

Scientific consortium maps the range of genetic diversity in Asia, and traces the genetic origins of Asian populations : HUGO Matters



Scientific consortium maps the range of genetic diversity in Asia, and traces the genetic origins of Asian populations : HUGO Matters

OVA 1 - The Biomarkers That Could: How Five Biomarkers Might Be the Key to Vermillion's Turnaround | ProteoMonitor | Proteomics | GenomeWeb



The Biomarkers That Could: How Five Biomarkers Might Be the Key to Vermillion's Turnaround | ProteoMonitor | Proteomics | GenomeWeb

Colorectal Cancer Incidence and Postmenopausal Hormone Use by Type, Recency, and Duration in Cancer Prevention Study II — Cancer Epidemiology, Biomarkers & Prevention




The Assessment and Management of Delirium in Cancer Patients -- Bush and Bruera, 10.1634/theoncologist.2009-0122 -- The Oncologist




multinational study: European Journal of Cancer : Autoantibody profiling to identify biomarkers of key pathogenic pathways in mucinous ovarian cancer




European Journal of Cancer : ONCOPOOL – A European database for 16,944 cases of breast cancer




MicroRNAs in Ovarian Carcinomas



Medline Abstract

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MicroRNAs in Ovarian Carcinomas.
Neetu Dahiya and Patrice Morin
Endocr. Relat. Cancer, November 10, 2009; .

N Dahiya, Lab Cell Molec Biol, NIH, Baltimore, United States.


The molecular mechanisms involved in epithelial ovarian cancer initiation and progression are just beginning to be elucidated. In particular, it has become evident that microRNAs (miRNAs), a class of molecules that post-trancriptionally regulates gene expression, play a major role in ovarian tumorigenesis. Several miRNA profiling studies have identified changes in miRNA patterns that take place during ovarian cancer development. While most deregulated miRNAs are down-regulated in cancer, and may therefore act as tumor suppressors, others are elevated and may represent novel oncogenes in this disease. A number of miRNAs identified as aberrantly expressed in ovarian carcinoma have been shown to have important functional roles in cancer development and may therefore represent targets for therapy. In addition, some of the miRNA patterns may have prognostic significance. The identification of functional targets represents a major hurdle in our understanding of miRNA function in ovarian carcinoma, but significant progress is being made. It is hoped that a better understanding of the miRNA expression and roles in ovarian cancer may provide new avenues for the detection, diagnosis, and therapy of this deadly disease.

PMID: 19903743

ORLive, Inc. and U.S. National Library of Medicine: Robot-Assisted Gynecologic Oncology Surgery




Model Compares Impact of Breast Cancer Mutations - Related study shows mutations to be associated with a lower response to fertility treatment - Modern Medicine