Wednesday, January 20, 2010
The DCLG indentifies and responds to issues and challenges facing the Institute at the request of the Director. The DCLG provides relevant, non-scientific skills and perspectives in order to improve research outcomes by identifying new approaches, promoting innovation, recognizing unforeseen risks or barriers, and identifying unintended consequences that could result from NCI decisions.
full free access: Identifying the barriers to conducting outcomes research in integrative health care clinic settings
"..... as IHC clinics are often complex systems, a whole systems approach to research should be used taking into account the multidimensional and complex nature of such treatment systems so that the results are useful and reflect real life."
Dec 2009 article: Influenza Vaccination in Immune Compromised Persons: Practical Advice for Oncologists - OncologySTAT
Note: if you are unable to view the full article then you need to register (it's free)
abstract: Combining Targeted Therapies: Practical Issues to Consider at the Bench and Bedside -- The Oncologist
"Recent and continuing developments in high-throughput and multiplexed assay platforms as well as in disciplines such as bioinformatics and biostatistics will surely shape the future of clinical trials. Application of novel techniques in a comprehensive approach, revealing the interrelations among targets and the mechanisms of action underlying cancer (systems biology), may lead to comprehensive diagnostic tools (systems pathology) and specific combinations of drugs (cocktails of monoclonal antibodies, RNA therapeutics, or others) in what has been called the actualization of personalized medicine. We know that momentum in the era of targeted therapy will continue to accelerate, bringing new hope to our patients
with cancer and their families"
Abstract/free full access: High penetrances of BRCA1 and BRCA2 mutations confirmed in a prospective series
define: deleterious = harmful
Note: genetic modifying factors of penetrance = factors which result in lower or high risks of cancer
These are important issues for us as patients/caregivers:
"Less than half were based on an explicit definition of quality of dying and death and even fewer relied on a conceptual model that incorporated multidimensionality and subjective determination.The specified duration of the dying and death phase ranged from the last months to hours of life."