Wednesday, March 17, 2010
news article: Another Reason Not to Get Your Genes Scanned (gene variants)
"Scientists have discovered numerous gene variants that slightly boost the risk of breast cancer, heart disease, and other common illnesses in recent years. It’s pioneering science. But is the deluge of genetic data useful for doctors and patients?..."
press release: New Data Indicate Effectiveness of Clarient's Ovotax(TM) Test for Ovarian Cancer "TLE3"
The study summary and results may be found at http://www.clarientinc.com/Ovotax
ALISO VIEJO, Calif., March 17 /PRNewswire-FirstCall/ -- Clarient, Inc. (Nasdaq: CLRT), a premier technology and services resource for pathologists, oncologists and the pharmaceutical industry, today announced that data from a new study shows that Clarient's Ovotax™ assay may effectively predict which ovarian cancer patients will respond favorably to taxane therapy and could, therefore, be spared the potential side effects of this rigorous and sometimes toxic chemotherapy agent. The study was presented yesterday at the national meeting on Women's Cancer of the Society of Gynecologic Oncologists by Janelle Fauci, M.D. of the Department of Obstetrics and Gynecology at the University of Alabama, Birmingham (UAB).
The study, titled "Expression of TLE3 Predicts Response to Taxane Therapy in Ovarian Carcinoma," included 293 carcinoma samples. Ovotax is a single antibody immunohistochemistry test created to detect the expression of TLE3 in an ovarian tumor and thereby indicate whether the patient will respond favorably to taxane therapy.
CBC News - Nfld. & Labrador - Danny Williams lashes out at N.L. doctors (pathology issues)
"You know what is missing in all of this is, which is the most important thing, which is what we worry about, what the minister of health worries about, is the patient. Where's the patient in all of this? Did Mr. Ritter or Dr. Lewis, or anybody who is trying to point the finger at the minister, talk about the patient?"
U.S. Director's Consumer Liaison Group - Genomis program/update
The meeting focuses on NCI genomics programs, including
updates and discussion of The Cancer Genome Atlas (TCGA). TCGA is NCI’s
comprehensive program to map the genetic changes involved in cancer. In
addition to a focus on genomic research in cancer, the DCLG will engage in
discussion with the NCI Director about the NCI budget and resource
constraints. A draft agenda will be
available online shortly.
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Schedule:
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Wednesday, March 24
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Thursday, March 25
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Friday, March 26
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2:00 p.m. to 5:00 p.m.
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8:30 a.m. to 5:00 p.m.
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8:30 a.m. to 12:30 p.m.
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update - OVA1 in Canada
I just received a message from OVA1 that the test is available in Canada, so I have resent another message asking for locations and cost. Stay tuned....
Omega-3 fatty acids for neuropathic pain: case series
CONCLUSIONS: This first-ever reported case series suggests that omega-3 fatty acids may be of benefit in the management of patients with neuropathic pain. Further investigations with randomized controlled trials in a more specific neuropathic pain population would be warranted.
Bilateral Oophorectomy versus Ovarian Conservation: Effects on Long-term Women's Health
J Minim Invasive Gynecol. 2010 March - April
Bilateral Oophorectomy versus Ovarian Conservation: Effects on Long-term Women's Health.
Parker WH.
John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, California.
Bilateral oophorectomy at the time of hysterectomy for benign disease is commonly practiced to prevent the subsequent development of ovarian cancer. Currently, bilateral oophorectomy is performed in 55% of all U.S. women having a hysterectomy, with approximately 300 000 prophylactic oophorectomies performed every year. Observational studies show that estrogen deficiency, resulting from premenopausal or postmenopausal oophorectomy, is associated with higher risks of coronary artery disease, stroke, hip fracture, Parkinsonism, dementia, cognitive impairment, depression, and anxiety. These studies suggest that bilateral oophorectomy may do more harm than good. In women not at high risk for development of ovarian or breast cancer, removing the ovaries at the time of hysterectomy should be approached with caution.
text video: It's All Over Folks...The End of Publishing As We Know It
eg. books, social media Entertaining video prepared by the UK branch of Dorling Kindersley Books. Originally meant solely for a DK sales conference, the video was such a hit internally that it is now being shared externally. ...
abstract: Should access to fertility treatment be determined by female body mass index? Human Reproduction
"Studies have shown that the direct costs per live birth are no greater for overweight and obese women..... Restricting fertility treatment on the grounds of BMI would cause stigmatization and lead to inequity, feelings of injustice and social tension as affluent women manage to bypass these draconian restrictions."
full free access: Human Ovarian Cancer Stem Cells -- Bapat, 10.1530/REP-09-0389 -- Reproduction
In research - selected notes:
Stem cells exist in ovarian tumors.
Editorial: Diet and Survival after Ovarian Cancer: Where Are We and What's Next?
Note: pay-per-view
Research
Diet and Survival after Ovarian Cancer: Where Are We and What's Next?
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