Monday, March 22, 2010
Medical News: SGO: Angiogenesis Inhibitor Scores Split Decision - in Meeting Coverage, SGO (enzastaurin and bevacizumab (Avastin)
The discovery of RNA interference, the mechanism by which double strands of RNA silence genes, won researchers Andrew Fire and Craig Mello the 2006 Nobel Prize in Physiology or Medicine.... "RNAi is a new way to stop the production of proteins," says Davis. What makes it such a potentially powerful tool, he adds, is the fact that its target is not a protein. The vulnerable areas of a protein may be hidden within its three-dimensional folds, making it difficult for many therapeutics to reach them. In contrast, RNA interference targets the messenger RNA (mRNA) that encodes the information needed to make a protein in the first place. "In principle," says Davis, "that means every protein now is druggable because its inhibition is accomplished by destroying the mRNA. And we can go after mRNAs in a very designed way given all the genomic data that are and will become available."
"Arrayit's OvaDx Pre-Symptomatic Ovarian Cancer Test will be the market's first comprehensive diagnostic screen for ovarian cancer, and will be recommended for all women over the age of 35. OvaDx uses approximately 100 proteomic biomarkers in a microarray format to identify molecular beacons of ovarian cancer that accumulate in the bloodstream as a result of the body's natural immune response to developing ovarian tumors. Arrayit's microarray test, which detects both early and late stage ovarian cancer..."cont'd
"...However, the test's low specificity raised some concern, as verbalized by an invited discussant of the study." MedPage Today Action Points * Explain to patients that in this study, use of a laboratory test improved the presurgical evaluation of ovarian tumors compared with physician clinical assessment alone. * Note that the test is for preoperative assessment of ovarian tumors and is not a screening or diagnostic test. * Note that this study was published as an abstract and presented at a conference. These data and conclusions should be considered to be preliminary until published in a peer-reviewed journal.