Thursday, March 25, 2010
Note: Dr Oza speaks briefly about a new endometrial cancer therapy and mentions ovarian cancer
CCR Connections (News NIH) - Big Things in Small Packages: Small RNAs Play a Big Role in Cancer Biology
"Exquisitely tuned gene expression is essential to orchestrate both the development and functioning of the myriad cell types in the human body. When that tuning goes awry, one result is cancer. Small microRNAs (miRNAs) have emerged relatively recently as key modulators of gene expression, acting at a stage between transcription of the genes and translation into proteins. Although they are tiny, miRNAs—at a little over 20 nucleotides long—pack a big punch since each regulates a variety of genes, and they are involved in diverse pathological processes, including cell proliferation and death...."
CCR Connections (News at NIH) - A Cure for the Incurable? Using the Body's Immune System to Treat Metastatic Cancers
Age and gender differences in symptom intensity and symptom clusters among patients with metastatic cancer
Note: abstract denotes 'common cancers' only, no reference to ovarian cancer
"Analyses of symptom clusters revealed that fatigue and drowsiness were included in the cluster of pain, nausea, and appetite in younger but not older patients. In men, pain clustered together with depression and anxiety; for women, physical and psychological symptoms formed separate clusters.
CONCLUSIONS: In patients with advanced cancers, symptom patterns differ according to age and gender. Palliative interventions tailored for symptoms that are more prominent in specific patient subgroups may offer greater therapeutic benefit."