Monday, April 26, 2010
full free access: PLoS ONE: Genetic Analysis of the Early Natural History of Epithelial Ovarian Carcinoma
Together, these data indicate that EOC frequently arises in ovarian cystic inclusions, is preceded by an identifiable dysplastic precursor lesion, and that increased cell proliferation, decreased apoptosis, and aneuploidy are likely to represent very early aberrations in ovarian tumorigenesis.
Important: see post April 26th - full free access:
PLOS One: Genetic Analysis of the Early Natural History of Epithelial Ovarian Carcinoma
"This is the first study giving very strong evidence that a substantial number of ovarian cancers arise in inclusion cysts and that there is indeed a precursor lesion that you can see, put your hands on, and give a name to," lead author Jeff Boyd, chief scientific officer at Fox Chase Cancer Center in Philadelphia, said in a news release. "Ovarian cancer most of the time seems to arise in simple inclusion cysts of the ovary, as opposed to the surface epithelium."...cont'd
Ontario Institute for Cancer Research Announces Three New Equity Investments -- TORONTO, April 26 /PRNewswire/ --
Note: press release has further information on the investments:
1)Novel Cellular Immunotherapy for Cancer;
2)Next Generation Biomarker Analysis Technology;
3)Rapid, Sensitive Technology for Biomarker Analysis
"Lymphadenectomy was associated with significant improvement in survival (P<0.001) in patients with ovarian and uterine carcinosarcomas, but the procedure was not performed as often in those with ovarian disease.
"Improved survival observed in the lymphadenectomy group argues in favor of routinely performing lymph node dissection in patients with uterine and ovarian carcinosarcoma," Gunjal Garg, MD, of Detroit Medical Center, and colleagues concluded in a poster presentation at the American Association for Cancer Research.
Carcinosarcomas are malignant mixed mullerian tumors. Carcinosarcomas that arise in the female genital tract are rare but associated with poor prognosis. Previous studies demonstrated that tumors of similar histology and originating in nearby organs might be biologically distinct entities because of involvement with different molecular pathways, Garg and colleagues noted..."cont'd
Computers in Human Behavior : Empowering processes in online support groups among people living with HIV/AIDS: A comparative analysis of ‘lurkers’ and ‘posters’
Note: 'lurker'/online study
The Human Genome Organisation (HUGO)