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Wednesday, May 12, 2010

IN-CAM Outcomes Database (CAM)



About IN-CAM:

Purpose

We have developed a database of outcome measures of particular importance to Complementary and Alternative Medicine (CAM) research in order to facilitate and support the assessment of CAM interventions through high quality research, and thus, to improve clinical practice and inform policy.

link- outcomes database/background:
http://www.outcomesdatabase.org/show/category/id/13

about the team:
http://www.outcomesdatabase.org/show/category/id/12

LISTSERV Choice Awards - Spread the Word - Nominate our ACOR listserv!



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FAQ and link to FAQ:
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The 2009-10 contest is open for nominations. Nominations must be received via the Web form by 6 p.m. Central European Time, June 1, 2010. We highly encourage participants to nominate their favorite lists as soon as possible so that the public will have ample time to vote for the lists.
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  • The top three finalists will be announced Spring 2010.

Review Unmasking the complexities of mucinous ovarian carcinoma



Note: mucinous/KRAS is also prevalant in colorectal cancers

Conclusions

Primary mucinous ovarian cancer should be considered separate from the other epithelial ovarian cancers. Ongoing clinical trials in this disease will likely offer improvements in chemotherapeutic agents used to treat women with primary and recurrent mucinous ovarian cancer.

Phase I clinical trials in 85 patients with gynecologic cancer: The M. D. Anderson Cancer Center experience



Note: the abstract does not detail outcomes/disease specific sites

Clinical relevance of rare germline sequence variants in cancer genes



Clinical relevance of rare germline sequence variants in cancer genes: evolution and application of classification models.

Abstract

Multifactorial models developed for BRCA1/2 variant classification have proved very useful for delineating BRCA1/2 variants associated with very high risk of cancer, or with little clinical significance. Recent linkage of this quantitative assessment of risk to clinical management guidelines has provided a basis to standardize variant reporting, variant classification and management of families with such variants, and can theoretically be applied to any disease gene. As proof of principle, the multifactorial approach already shows great promise for application to the evaluation of mismatch repair gene variants identified in families with suspected Lynch syndrome. However there is need to be cautious of the noted limitations and caveats of the current model, some of which may be exacerbated by differences in ascertainment and biological pathways to disease for different cancer syndromes.

Cancers of the breast, uterus, ovary and cervix among Alaska Native women, 1974-2003




abstract: The inherited genetics of ovarian and endometrial cancer



"Endometrial and epithelial ovarian cancers are the fourth and fifth most common cancers in women in developed countries, after breast, lung, and colorectal cancer. In the United States alone, in 2008 there were about 40000 new diagnoses of endometrial cancer and 7500 disease-related deaths. For ovarian cancer, there were about 22000 new diagnoses and 15000 deaths over the same period. The purpose of this article is to review the recent developments in the inherited genetics of ovarian and endometrial cancer, with particular attention to recent progress in identifying common low-penetrance susceptibility genes and their clinical implications."

The origin of serous ovarian cancer may be found in the uterus: A novel hypothesis




Editorial: The cancer of bureaucracy: How it will destroy science, medicine, education; and eventually everything else



Editorial

The cancer of bureaucracy: How it will destroy science, medicine, education; and eventually everything else

Summary

Everyone living in modernizing ‘Western’ societies will have noticed the long-term, progressive growth and spread of bureaucracy infiltrating all forms of social organization: nobody loves it, many loathe it, yet it keeps expanding. Such unrelenting growth implies that bureaucracy is parasitic and its growth uncontrollable – in other words it is a cancer that eludes the host immune system. Old-fashioned functional, ‘rational’ bureaucracy that incorporated individual decision-making is now all-but extinct, rendered obsolete by computerization. But modern bureaucracy evolved from it, the key ‘parasitic’ mutation being the introduction of committees for major decision-making or decision-ratification. Committees are a fundamentally irrational, incoherent, unpredictable decision-making procedure; which has the twin advantages that it cannot be formalized and replaced by computerization, and that it generates random variation or ‘noise’ which provides the basis for natural selection processes. Modern bureaucracies have simultaneously grown and spread in a positive feedback cycle; such that interlinking bureaucracies now constitute the major environmental feature of human society which affects organizational survival and reproduction. Individual bureaucracies must become useless parasites which ignore the ‘real-world’ in order to adapt to rapidly-changing ‘bureaucratic reality’. Within science, the major manifestation of bureaucracy is peer review, which – cancer-like – has expanded to obliterate individual authority and autonomy. There has been local elaboration of peer review and metastatic spread of peer review to include all major functions such as admissions, appointments, promotions, grant review, project management, research evaluation, journal and book refereeing and the award of prizes. Peer review eludes the immune system of science since it has now been accepted by other bureaucracies as intrinsically valid, such that any residual individual decision-making (no matter how effective in real-world terms) is regarded as intrinsically unreliable (self-interested and corrupt). Thus the endemic failures of peer review merely trigger demands for ever-more elaborate and widespread peer review. Just as peer review is killing science with its inefficiency and ineffectiveness, so parasitic bureaucracy is an un-containable phenomenon; dangerous to the extent that it cannot be allowed to exist unmolested, but must be utterly extirpated. Or else modernizing societies will themselves be destroyed by sclerosis, resource misallocation, incorrigibly-wrong decisions and the distortions of ‘bureaucratic reality’. However, unfortunately, social collapse is the more probable outcome, since parasites can evolve more rapidly than host immune systems.

abstract - Jjournal of Medical Hypostheses: Determinants of geographic patterns of diseases: Interaction of lactose/lactase status and sunshine exposure. (vitamin D)



Note: in research

"Then in a preliminary fashion lactose digester and maldigester status are related to relative annual sunshine exposure. Further the relative national annual sunshine exposure is evaluated to outcomes of the same exemplary diseases. The patterns related to sunshine reflect that obtained with national lactase status proportions and also corroborate a literature review. However, correlations are weak to moderate and only ovarian cancer reached conventional statistical significance. Because these comparisons are based on modest number of national data firm conclusions cannot be made.....These could partly explain both north to south and west to east directional changes.