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Saturday, May 29, 2010

Hormone therapy, DNA methylation and colon cancer-- Carcinogenesis




(Pre-)Clinical Pharmacology and Activity of Pazopanib, a Novel Multikinase Angiogenesis Inhibitor




CCR Clinical Trials at NIH: Clinical Research: Search for Clinical Trials at NIH ovarian cancer Results = 5




Effect of BRCA2 sequence variants predicted to disrupt exonic splice enhancers on BRCA2 transcripts




BACKGROUND:
Genetic screening of breast cancer patients and their families have identified a number of variants of unknown clinical significance in the breast cancer susceptibility genes, BRCA1 and BRCA2.

CONCLUSIONS:
These results illustrate the need for improved methods for predicting functional ESEs and the potential consequences of sequence variants contained therein.

Patient navigation in breast cancer: a systematic review



Note: the abstract does not provide a definition of 'patient navigator'

IMPLICATIONS FOR PRACTICE: Data describing the role of patient navigation in breast cancer will assist in better defining future direction for the breast navigation role. Ongoing research will better inform issues related to role definition, integration into clinical breast cancer care, impact on quality of life, cost-effectiveness, and sustainability.

Randomized Phase 2 Dose-finding Study of Weekly Administration of Darbepoetin Alfa in Anemic Patients with Lung or Ovarian Cancer Receiving Multicycle Platinum-containing Chemotherapy



Novartis's patupilone fails in ovarian cancer trial | Reuters