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Saturday, October 02, 2010

abstract: Managing menopausal symptoms and depression in tamoxifen users: Implications of drug and medicinal interactions



OBJECTIVE: Tamoxifen, a medication used in the treatment of breast cancer, often induces menopausal symptoms. Certain medications and natural supplements taken or prescribed to alleviate tamoxifen-induced hot flashes and depressive states in women with breast cancer interact with tamoxifen. This paper reviews potentially problematic interactions and offers treatment recommendations.
CONCLUSIONS: Clinicians should remain cautious about using strong inhibitors and/or inducers of cytochrome 2D6 and 3A4 concomitantly with tamoxifen. Use of natural menopausal supplements and diets rich in isoflavones should not be encouraged in tamoxifen users until more data is available. There are however safe treatments for hot flashes and depression in tamoxifen users.

abstract: Treatment of bevacizumab-induced hypertension by Amlodipine



Also reference:
NORVASC® (amlodipine besylate) Tablets for Oral Administration

http://www.rxlist.com/norvasc-drug.htm

Mayo Clinic - Mayo Clinic Review of Ethical Decision Making With End-of-Life Care




Research integrity: Sabotage! : Nature News




MOCA - OvaryAct! | Minnesota Ovarian Cancer Alliance (MOCA)




Mayo Clinic Hosts Women's Cancers 2010: Merging Science and Care Oct. 2 PressReleasePoint



"Global Top 20" Shows US and UK Have the Most Influential Experts in Breast Cancer Research



full free access: Rustin et al: Early versus delayed treatment of relapsed ovarian cancer (MRC OV05/EORTC 55955): a randomised trial : The Lancet



Note: full free access is available/registration (free) is required to view

Q: Should healthy people take a multivitamin? — Cleveland Clinic Journal of Medicine



Helping Someone With Cancer - medical article



abstract: Does Neoadjuvant (Avastin) Bevacizumab Increase Surgical Complications in Breast Surgery?



Conclusions Cisplatin/bevacizumab and cisplatin alone neoadjuvant therapy resulted in a significant number of postoperative complications. Specifically, use of expanders/implants may be problematic for patients treated with bev. However, this was a single-arm trial; randomized controlled studies will be needed to determine the optimal use of bevacizumab in the timing of breast cancer surgery.

abstract: Does Neoadjuvant Bevacizumab Increase Surgical Complications in Breast Surgery?



Memory Impairment Common in People with a History of Cancer « AACR News



"He calls the condition “cancer related cognitive dysfunction,” suggesting that it goes beyond the “chemobrain” label that has been attached primarily to women treated with chemotherapy for their breast cancer who reported problems in cognitive function (e.g., attention and memory). “These memory issues can be related to treatment, such as chemotherapy, radiation, and hormone therapies, or to the tumor biology itself, which could change brain chemistry and neurobehavioral function,” said Jean-Pierre."