Thursday, December 23, 2010
"...That began to change earlier this decade as scientists discovered that microRNAs might actually be the hidden regulators that control the 30,000 genes in the human body by silencing gene expression.....One in particular, miR-31, discovered by Baylor collaborators and Gunaratne, shows promise as a potent tumor suppressor in ovarian cancer, glioblastoma, osteosarcoma and prostate cancer.......They discovered that miR-31 can specifically target and kill cancer cells that are deficient in p53, a crucial gene that guards the integrity of the genome and prevents cancer. More than half of all cancers and 90 percent of papillary serous tumors - the most common type of malignant ovarian cancer - are p53-deficient."
Serrated polyps of the colon
Aravind Sugumar and Frank A Sinicrope
Division of Gastroenterology & Hepatology and Division of Oncology, Mayo Clinic and Mayo College of Medicine, 200 First Street SW, Rochester, MN 55905, USACorresponding author
F1000 Med Reports2010, 2:89 (doi: 10.3410/M2-89)
Published: 17 Dec 2010"....Among the more important findings is that SSAs may be the precursor lesions for MSI-H colon cancers. Furthermore, there is evidence that serrated polyps are more likely to be missed during colonoscopy [10,11,22]. As a result, colonoscopic follow-ups for serrated adenomas should be the same as for conventional adenomatous polyps...."