Free Full-Text - IJMS ( Intl Jnl of Molecular Sciences) Exploring the Immunoproteome for Ovarian Cancer Biomarker Discovery

Published: 14 January 2011

(This article belongs to the Special Issue Cancer Molecules in Ovarian Cancer)

Download PDF Full-Text [1380 KB, uploaded 14 January 2011 15:39 CET]

Abstract:  

Most scientific efforts towards early detection of ovarian cancer are commonly focused on the discovery of tumour-associated antigens (TAA). Autologous antibodies against TAA, however, may serve as more sensitive diagnostic markers. They circulate in the blood before TAA and are usually more abundant than the TAAs themselves as a result of amplification through the humoral immune response. Accumulating evidence also suggests that a humoral response already exists during malignant transformation when aberrant gene expression is translated into premalignant cellular changes. This article reviews the current knowledge about autoantibodies against TAA in ovarian cancer and presents current immunoproteomic approaches for their detection.

full free access: eMJA: When do I know I am cured? Using conditional estimates to provide better information about cancer survival prospects

See also (abstract) reference #7:

Choi M, Fuller CD, Thomas CR Jr, et al. Conditional survival in ovarian cancer: results from the SEER dataset 1988–2001. Gynecol Oncol 2008; 109: 203-209. <PubMed>