Saturday, May 07, 2011
Apr 2011 audio/slide presentation: Population-Based Screening and Cascade Testing for Lynch Syndrome: Are We There Yet? « DAVE Project – Gastroenterology
Dr Vincent Yang, Director of the Division of Digestive Diseases at Emory University School of Medicine, presented clinical grand rounds at the MGH GI Unit. The topic was screening for Lynch Syndrome (HNPCC). The presentation was recorded 19 April 2011.
"Occurrence: 1 in 1000 live births"
MSH2/MLH1 usually = MSI-H
"....did not follow up on an abnormal biopsy on a 42-year-old patient who received fertility treatment, delaying her diagnosis of ovarian cancer for months....."
abstract: Intraoperative Neuraxial Anesthesia But Not Postoperative Neuraxial Analgesia Is Associated With Increased Relapse-Free Survival in Ovarian Cancer Patients After Primary Cytoreductive Surgery
Regional anesthesia has been shown to blunt the response to surgical stress and decrease the use of volatile anesthetics and the consumption of opioids, which may reduce immune compromise and potentially delay tumor recurrence. The goal of this study was to find a possible association between intraoperative regional anesthesia and decreased cancer recurrence.
Intraoperative use of epidural anesthesia was associated with an increased time to tumor recurrence after surgery in ovarian cancer patients. This may be a result of preservation of the immune system function.