Bionomics - News - new trials phase 1/11 announced - BNC105 (combo)

Ovarian cancer trial planned:

• Randomised Phase I/II trial of BNC105 in combination with carboplatin and gemcitabine
• Preclinical data support use of BNC105 in combination with platinum (cisplatin; carboplatin) based therapeutic regimens

Quantitative and Functional Alterations of Plasmacytoid Dendritic Cells Contribute to Immune Tolerance in Ovarian Cancer

Note: in research/technical

Abstract

"In ovarian cancer, the immune system fails to eradicate established tumors partly due to the induction of immune tolerance within tumor microenvironment.....cont'd

Modification of BRCA1-Associated Breast and Ovarian Cancer Risk by BRCA1 Interacting Genes

"Overall, the data suggest that genomic variation at multiple loci that encode proteins that interact biologically with BRCA1 are associated with modified breast cancer and ovarian cancer risk in women who carry BRCA1 mutations."

Tea Consumption and Epithelial Ovarian Cancer Risk: A Systematic Review of Observational Studies

Use of SAND Balloon Catheter for Laparoscopic Management of Extremely Large Ovarian Cysts (intraperitoneal spillage)

"With proper patient selection, the SAND balloon catheter can be extremely useful in laparoscopic removal of very large adnexal masses, without intraperitoneal spillage."

Use of metformin and the risk of ovarian cancer: A case-control analysis

OBJECTIVE:

To explore the association between use of metformin or other antidiabetic drugs and the risk of ovarian cancer.

CONCLUSION:

In this large epidemiological study long-term use of metformin, but not of sulfonylureas, was associated with a tendency towards a decreased risk of ovarian cancer. Long-term use of insulin was associated with an increased risk of ovarian cancer.

Laparoscopic Intraperitoneal Port Placement for Optimally Cytoreduced Advanced Ovarian Cancer

p53 Signature and Serous Tubal In-situ Carcinoma in Cases of Primary Tubal and Peritoneal Carcinomas and Serous Borderline Tumors of the Ovary

Clear Cell Adenocarcinoma With a Component of Poorly Differentiated Histology: A Poor Prognostic Subgroup of Ovarian Clear Cell Adenocarcinoma

Ovarian Yolk Sac Tumors in Older Women Arising From Epithelial Ovarian Tumors or With No Detectable Epithelial Component

Luteinized Adult Granulosa Cell Tumor-A Series of 9 Cases: Revisiting a Rare Variant of Adult Granulosa Cell Tumor

Neoadjuvant chemotherapy for advanced ovarian cancer: overview of outcomes and unanswered questions.

An Observational Study of (Avastin) Bevacizumab-Induced Hypertension as a Clinical Biomarker of Antitumor Activity

Anti-Müllerian hormone inhibits growth of AMH type II receptor-positive human ovarian granulosa cell tumor cells by activating apoptosis

Preneoplasias of ovarian carcinoma : Biological and clinical aspects of different pathways of tumorigenesis