Abstract
We
assessed associations between steroid receptors including:
estrogen-alpha, estrogen-beta, androgen receptor, progesterone receptor,
the HER2 status and triple-negative epithelial ovarian cancer (ERα-/PR-/HER2-; TNEOC) status and
survival in women with epithelial
ovarian cancer. The study included
152 women with primary epithelial
ovarian cancer.
The status of steroid receptor and HER2 was determined by
immunohistochemistry. Disease-free and overall survival were calculated
and compared with steroid receptor and HER2 status as well as
clinicopathological features using the Cox Proportional Hazards model. A
mean follow-up period of 43.6 months (interquartile range=41.4 months)
was achieved where
44% of patients had serous tumor, followed by
mucinous (23%), endometrioid (9%), mixed (9%), undifferentiated (8.5%)
and clear cell tumors (5.3%). ER-alpha staining was associated with
grade II-III tumors. Progesterone receptor staining was positively
associated with a Body Mass Index≥25. Androgen receptor positivity was
higher in serous tumors. In stand-alone analysis of receptor
contribution to survival, estrogen-alpha positivity was associated with
greater disease-free survival. However, there was no significant
association between steroid receptor expression, HER2 status, or TNEOC
(
ERα-/PR-/HER2-; TNEOC) status, and overall survival. Although estrogen-alpha, androgen
receptor, progesterone receptor and the HER2 status were associated with
key clinical features of the women and pathological characteristics of
the tumors, these associations were not implicated in survival.
Interestingly, women with TNEOC seem to fare the same way as their
counterparts with non-TNEOC.
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