|
|
|
|
|
|
|
|
abstract
Objective: The aims of this study were to compare the
rate of completion of optimal debulking and/or 6 cycles of
intraperitoneal (IP) chemotherapy in women with International Federation
of Gynecologists and Obstetricians stage III/IV ovarian cancer
undergoing neoadjuvant chemotherapy (NACT) versus primary surgery (PS)
and to compare morbidity between these 2 groups.
Methods: Ninety-six subjects with stage III/IV ovarian
cancer who underwent either NACT or PS were identified. Data comparisons
include rate of optimal debulking and completion rate of 6 cycles of IP
chemotherapy. Other data collected included surgical times, length of
stay, intensive care unit admissions, blood transfusions, bowel
resections, major complications, and dose reductions. SigmaStat version
2.0 was used for statistical analysis.
Results: Of the 96 subjects, 38 received NACT and 58 had
PS. All 14 subjects with stage IV disease received NACT, and all
experienced resolution of pleural effusion, based on computed
tomographic imaging. Thirty-five (92%) of 38 NACT subjects versus 47
(81%) of 58 PS subjects were optimally debulked (P = 0.08). Thirty-six
(95%) of 38 NACT subjects versus 37 (64%) of 58 PS subjects completed IP
chemotherapy (P < 0.001). Length of stay was 3.26 (NACT) versus 5.08
(PS) days (P < 0.001). Intensive care unit admissions were 1 of 38
(NACT) versus 12 of 58 (PS) (P < 0.001). Bowel resections were done
in 2 of 38 (NACT) versus 14 of 38 (PS) (P < 0.05). Duration of
surgery was 96 minutes (NACT) versus 138 minutes (PS) (P < 0.001). A
trend to fewer dose reductions occurred in NACT (1/38) versus PS (8/58)
(P = 0.056).
Conclusions: The NACT subjects were more likely to
complete IP chemotherapy and had decreased length of stay, intensive
care unit admissions, bowel resections, and duration of surgery. Both
optimal debulking and dose reductions were numerically but not
statistically associated with NACT versus PS. This likely reflects a
relatively high overall rate of optimal debulking and low rate of dose
reductions in these subjects and would require a larger group to
determine significance.
0 comments :
Post a Comment
Your comments?
Note: Only a member of this blog may post a comment.