Bilateral ovarian metastases from ureteric urothelial cancer: Initial case report and distinguishing role of immunohistochemistry

 Blogger's Note: of interest to Lynch Syndrome patients

abstract
 
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Abstract

Urothelial cancers of the upper tract are aggressive malignancies with a propensity for distant metastases. Transitional cell carcinoma can also develop de novo in the ovaries and differentiation between these lesions requires immunohistochemistry. We report a case of right lower ureteric urothelial carcinoma with metastases to both ovaries. To our knowledge, this is the first reported case of bilateral ovarian metastases from an upper tract primary, diagnosed with immunohistochemistry.

 

"... CK20 expression is specific for urinary tract origin.5 In our
case, the ovarian lesions were positive for CK7 and CK20,
and negative for WT1, indicating the primary was in the
urinary tract. Differentiation is important as ovarian primaries
are more chemosensitive and have a better prognosis.5"