...patient self-administered cancer family history questionnaire in identification of gyn cancer pts suspected of Lynch syndrome (Japan) Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Monday, June 29, 2015

...patient self-administered cancer family history questionnaire in identification of gyn cancer pts suspected of Lynch syndrome (Japan)



abstract
  
Usefulness of the patient self-administered cancer family history questionnaire in identification of gynecological cancer patients suspected of Lynch syndrome: KCOG-G1302 study
  
Background: Detailed family history collection is necessary to detect gynecological cancer patients suspected of Lynch syndrome (LS). However, clinicians have little time for family history interviews. In addition, there is a lack of genetic counselors in Japan. Therefore, information from medical records on the first visit (MR) is insufficient to determine if a patient may be at risk of LS. We showed that using the self-administered cancer family history questionnaire (SACFHQ) improves identification of patients suspected of LS.  

Methods: We recruited endometrial or ovarian cancer patients already diagnosed or newly diagnosed from research participating institutions. After consent was obtained, participants completed the questionnaire. By referring to the cancer family history obtained from MR and SACFHQ, we referred to cases that met the Amsterdam criteria II(AMSII), the SGO20-25% criteria (SGO20-25%), ACOG’s clinical bulletin 2014 criteria (ACOG2014).  

Results: There was a total of 493 participants. 38 patients were excluded by exclusion criteria. Finally, 455 were eligible. Median age at diagnosis was 56 (range21-84). 243 participants were endometrial cancer patients, and 213 were ovarian cancer, including peritoneal and tubal cancer. 12 cases had either synchronous/metachronous endometrial and colorectal cancer. 4 cases had either synchronous/metachronous ovarian and colorectal cancer. Among these 16 cases, endometrial or ovarian cancer was sentinel in 8 cases. By using MR, 0/455 (0%), 4/455 (0.9%), and 170/455 (37%) cases met AMSII, SGO20-25%, ACOG2014 criteria, respectively. By using SACFHQ, 6/455 (1.3%), 9/455 (2.0%), and 217/455 (48%) cases met AMSII, SGO20-25%, ACOG2014 criteria, respectively. All 6 cases that met AMSII were endometrial cancer patients. 8 of 9 patients who met SGO20-25% were endometrial cancer patients, and one patient was ovarian cancer.  

Conclusions: Family cancer history obtained from MR was shown to be insufficient to identify individuals at risk of LS. SACFHQ (self-administered cancer family history questionnaire) improves identification of gynecological cancer patients suspected of LS. Clinical trial information: 000013192.

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