|
|
|
|
|
|
|
|
abstract
Impact of Age and Primary Disease Site on Outcome in Women With Low-Grade Serous Carcinoma of the Ovary or Peritoneum: Results of a Large Single-Institution Registry of a Rare Tumor
Purpose Low-grade
serous carcinoma of the ovary (LGSOC) or peritoneum (LGSPC) is a rare
subtype of ovarian or peritoneal cancer characterized
by young age at diagnosis and relative
resistance to chemotherapy. The purpose of this study is to report our
updated experience
with women diagnosed with LGSOC or LGSPC to
assess the validity of our original observations.
Patients and Methods
Eligibility criteria for patients from our database were: stage I to IV
LGSOC or LGSPC, original diagnosis before January
2012, and adequate clinical information. All
patients were included in progression-free survival, overall survival,
and multivariable
Cox regression analyses. A subset analysis was
performed among patients with stage II to IV low-grade serous carcinoma
treated
with primary surgery followed by platinum-based
chemotherapy.
Results We identified
350 eligible patients. Median progression-free survival was 28.1 months;
median overall survival was 101.7
months. In the multivariable analysis, compared
with women age ≤ 35 years, those diagnosed at age > 35 years had a
43% reduction
in likelihood of dying (hazard ratio, 0.53; 95%
CI, 0.37 to 0.74; P < .001). Having disease present at
completion of primary therapy was associated with a 1.78 increased
hazard of dying compared
with being clinically disease free (P
< .001). Similar trends were noted in the smaller patient cohort. In
this cohort, women with LGSPC had a 41% decreased chance
of dying (hazard ratio, 0.59; 95% CI, 0.36 to
0.98; P = .04) compared with those with LGSOC.
Conclusion Women age < 35 years with low-grade serous carcinoma and those with persistent disease at completion of primary therapy have
the worst outcomes. Patients with LGSPC seem to have a better prognosis than those with LGSOC.
0 comments :
Post a Comment
Your comments?
Note: Only a member of this blog may post a comment.