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" Early descriptions of UTUC in LS were limited by small patient numbers,
lack of pathological confirmation,
placement in the broad categories of
genitourinary malignancy (together with bladder or renal cell
carcinomas) or kidney malignancy (without distinguishing renal pelvis or
renal cell carcinoma) and no available molecular or genetic testing.
Not until the later introduction of the Amsterdam Criteria II
20 and the Bethesda Criteria
21 did patients with
extracolonic malignancies receive full consideration for study inclusion."
Article Outline
Purpose
Lynch
syndrome, also known as hereditary nonpolyposis colorectal cancer, is a
common genetic disease. The predisposition of patients with Lynch
syndrome to urological cancer, particularly upper tract urothelial
carcinoma, is
underappreciated. Urologists may be involved in several
aspects of care involving Lynch syndrome, including identifying
undiagnosed patients, surveillance of those with established Lynch
syndrome or screening family members, in addition to treating patients
with Lynch syndrome in whom upper tract urothelial carcinoma develops.
We sought to increase awareness in the urological community about Lynch
syndrome and provide some guidance where little currently exists.
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