Lynch Syndrome: A Primer for Urologists and Panel Recommendations - The Journal of Urology Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Friday, July 03, 2015

Lynch Syndrome: A Primer for Urologists and Panel Recommendations - The Journal of Urology



open access

" Early descriptions of UTUC in LS were limited by small patient numbers, lack of pathological confirmation, placement in the broad categories of genitourinary malignancy (together with bladder or renal cell carcinomas) or kidney malignancy (without distinguishing renal pelvis or renal cell carcinoma) and no available molecular or genetic testing. Not until the later introduction of the Amsterdam Criteria II20 and the Bethesda Criteria21 did patients with extracolonic malignancies receive full consideration for study inclusion."

 Article Outline

Purpose

Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer, is a common genetic disease. The predisposition of patients with Lynch syndrome to urological cancer, particularly upper tract urothelial carcinoma, is underappreciated. Urologists may be involved in several aspects of care involving Lynch syndrome, including identifying undiagnosed patients, surveillance of those with established Lynch syndrome or screening family members, in addition to treating patients with Lynch syndrome in whom upper tract urothelial carcinoma develops. We sought to increase awareness in the urological community about Lynch syndrome and provide some guidance where little currently exists.

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