abstract
[Early epithelial lesions in prophylactic annexectomies in patients
at high risk of ovarian cancer: Report of a series of 93 cases]
OBJECTIVE:
Tubal
lesions detected in specimen of risk reducing salpingo oophorectomy
(RRSO) for mutation BRCA1/2 seems to play a role in ovarian
carcinogenesis. The main objective of this study is to evaluate the
prevalence of
occult neoplasia, of Serous Tubal Intraepithelial
Carcinoma (STIC), and signature
P53 in a cohort of patients who
underwent a risk reducing salpingo oophorectomy.
METHODS:
From
January 2010 to January 2014 unicentric, retrospective study on a
consecutive cases cohort of RRSO for patients with a high risk of
ovarian neoplasia (mutation BRCA 1/2
or family history). Pathological
specimen should be analysed according to the SEE-FIM protocol.
RESULTS:
Ninety-three
RRSO were recorded. Among them, 44% of the patients had the germ line
mutation BRCA1, 30.1% BRAC2 and 18.2% had no identified mutation. In
all, 33.3% of the RRSO reveal a signature P53, in the fimbria for 93.9%,
7.9% of them were bilateral. 1,1‰ (n=1) of the patients presented a
unilateral STIC. We obtained 4.3% of occult neoplasia: 3 ovarian
high-grade serous carcinomas and 1 tubal high-grade serous carcinoma.
Only the tubal carcinoma coexists with STIC.
CONCLUSION:
5,4%
of the patients who underwent RRSO had a diagnostic of occult
neoplasia. One percent of the patients had an isolated STIC. These
results agree with recent data of the literature. Extensive examination
of the Fallopian tube opens up a new way to understand ovarian
carcinogenesis.
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