abstract
- The University of Texas MD Anderson Cancer Center Houston USA
- 2.Sackler Faculty of MedicineTel-Aviv University Tel AvivIsrael
- 3.Albany College of Pharmacy and Health Sciences Albany USA
- 4.Department of Gastroenterology Sheba Medical CenterTel-Hashomer, Ramat GanIsrael
Communication gaps in families with
unexplained mismatch repair (MMR)
deficiency (UMMRD) could negatively impact the screening behaviors of
relatives of individual with UMMRD. We evaluated cancer risk perception,
screening behaviors, and family communication among relatives of
colorectal cancer (CRC) patients with UMMRD. Fifty-one family members of
17 probands with UMMRD completed a questionnaire about cancer risk
perception, adherence to Lynch syndrome (LS) screening recommendations,
and communication with relatives. Clinical data about the probands were
obtained from medical records. Thirty-eight participants (78%) were
worried from having cancer and twenty-one participants (42%) had
undergone colonoscopy in the past 2 years, as recommended for LS
families.
In terms of screening for extracolonic cancers, only two
eligible participants (3.9%) were screened for gastric, endometrial
(10.0%), and ovarian (9.5%) cancers. Additionally, 5 participants (10%)
underwent genetic counseling.
Most participants were not told by anyone
to be screened for extracolonic cancers (84, 85, and 95% for gastric,
ovarian, and endometrial cancers, respectively). A minority of family
members of CRC patients with UMMRD follow cancer screening as
recommended for LS families. Health care providers should encourage
patients with UMMRD to share information on LS-related cancers
screening, especially extracolonic cancers, with their relatives.
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