Tuesday, April 12, 2011
National Coalition for Cancer Survivorship: Expense-Paid Training Opportunity on Oral Chemotherapy Adherence
Expense-Paid Training Opportunity on Oral Chemotherapy Adherence
The National Coalition for Cancer Survivorship (NCCS), the National Association of Social Workers (NASW), the Oncology Nursing Society (ONS) and the Association of Oncology Social Work (AOSW) are pleased to host a Train-the-Trainer conference on cancer oral medication adherence at the NASW National Office in Washington, DC on Wednesday June 15, 2011. This one-day conference will provide attendees with the knowledge and skills necessary to train their colleagues in promoting adherence to cancer oral medication among patients and their family members. 30 people will be selected to participate in this one-day training, which will be led by social work, nursing and pharmacy professionals. Preference will be given to team applications. Expenses related to the conference (travel, lodging and meals) will be covered by NASW. In the 12 months following the conference, each attendee will be required to train at least 20 of his/her professional peers. Applications Due: Monday, April 25th . Click here to download the application materials.Monday, April 11, 2011
Sunday, April 10, 2011
JAMA full free access: Health Outcomes After Stopping Conjugated Equine Estrogens Among Postmenopausal Women With Prior Hysterectomy-randomized control trial
Health Outcomes After Stopping Conjugated
Equine Estrogens Among Postmenopausal
Women With Prior Hysterectomy
(timeline) Landmarks From Two Decades of Study - NYTimes.com
By THE NEW YORK TIMES
Published: April 9, 2011
1991 National Institutes of Health embarks on a study of menopause hormones after observational data suggest that women who use hormones have lower rates of heart disease.
Related
-
The Women’s Health Initiative and the Body Politic (April 10, 2011)
2003 Women taking E+P are not protected from mild memory loss; they are found to be at increased risk for developing dementia.
2004 The second W.H.I. hormone study is stopped one year early because women taking estrogen only show a small increased risk of stroke.
2006 An updated analysis of the estrogen-only trial shows hormone therapy does not increase the risk of breast cancer in postmenopausal women.
2007 Combined data from both hormone trials suggest that timing of therapy may affect risk; hormones may reduce heart disease in women who start therapy closer to menopause.
2009 Women using E+P for more than about five years double their annual risk of breast cancer. That risk is higher than previously thought.
2011 Follow-up of women in the estrogen-only study shows those who took just estrogen had 23 percent fewer breast cancers; younger estrogen users had 46 percent fewer heart attacks.
Sources: Women’s Health Initiative; New York Times reports
Friday, April 08, 2011
abstract: Differences in regional brain metabolism associated with specific formulations of hormone therapy in postmenopausal women at risk for AD (Alzheimer's disease)
"In conclusion, particular areas of relatively preserved metabolism were seen in women with more years of endogenous estrogen exposure, as well as in women taking estradiol-based formulations or estrogen therapies unopposed by progesterone, together suggesting regionally specific neuroprotective estrogenic effects."
abstract: Sympathetic and parasympathetic activity in cancer-related fatigue: More evidence for a physiological substrate in cancer survivors
also media report
"Persistent fatigue that plagues many breast cancer survivors even 10 years after treatment may be caused by the autonomic nervous, U.S. researchers say.'
Thursday, April 07, 2011
Low Bowel Cancer (Colo-rectal cancer) Awareness In UK (in women)
"...In the UK, bowel cancer is the one of the top three most common cancers diagnosed in both men and women, yet nearly three quarters of the women included in the survey did not recognize the disease as being one of the three most prevalent cancers in women."
News: AACR: Talc Use Linked to Ovarian Cancer Risk - in Meeting Coverage, AACR Medpage news
"Menopausal status has a striking effect on the dose-response for the association," said Cramer. "Premenopausal women with frequent use may have more than a threefold increase in their risk for invasive serous cancer of the ovary. Repeating these analyses in existing data sets may help clarify the association between talc and ovarian cancer."
JCO: Oncology Conferences: Please Call It a Day
"....Despite the costs and resources involved, leading oncology organizations
plan conferences every year. Pre- and postconference events,
including conference-revisited events, are regular rituals after large
specialty conferences. But is the physical attendance of delegates at
conferences still required? Will the oncology community rise up and
stop this perennial waste of time, effort, and money and instead use
this money for a more scientific or nobler cause?5 One suggestion
would be to create a single global research fund to which all oncology
bodies and governments contribute and to which all nations,
both developed and developing, can apply for funding of their
trials. This would greatly improve the standards of global research
and enhance scientific pursuits."
Gain of Function: Empathy for the Uncertain Patient With Cancer - JCO The Art of Oncology series
"........But no matter how much time remains, and whether the goal of care is cure, control, or comfort, we can tell our patients with absolute certainty that we will not abandon them to the unknown."
April 2011 issue of CONVERSATIONS - The International Newsletter for Those Fighting Ovarian Cancer
Note: online version
Highlights of April 2011
Don’s Notes 1
Managing Your Fears and Anxieties 2
May Ovarian Cancer Survivor Course 3
Improving Care through Clinical trials 4
Suggestion/request from reader 4
Survivor Anniversaries for April 5
Upcoming Event 6
Tips for Traveling by Automobile 7
Resource: CarePages.com 7
Name change: From GCF to FWC 8
National Race to End Women’s Cancer 8
Survivor Course Schedule 8
June Ovarian Cancer Survivor Course 9
Grand Finale 10
Upper Urinary Tract Carcinoma in Lynch Syndrome Cases - Lynch et al/J Urology
Abstract
PURPOSE: Patients with Lynch syndrome are much more likely to have generally rare upper urinary tract urothelial carcinoma but not bladder urothelial carcinoma. While the risk has been quantified, to our knowledge there is no description of how this population of patients with Lynch syndrome and upper urinary tract cancer differs from the general population with upper urinary tract cancer.
MATERIALS AND METHODS: We obtained retrospective data on a cohort of patients with Lynch syndrome from the Hereditary Cancer Center in Omaha, Nebraska and compared the data to those on a control general population from western Sweden. These data were supplemented by a new survey about exposure to known risk factors.
RESULTS: Of the patients with Lynch syndrome 91% had mutations in MSH2 rather than in MSH1 and 79% showed upper tract urothelial carcinoma a mean of 15.85 years after prior Lynch syndrome-type cancer. Median age at diagnosis was 62 years vs 70 in the general population (p <0.0001). Only half of our patients had a significant smoking history and the male-to-female ratio was 0.95. Of patients with Lynch syndrome 51% had urothelial carcinoma in the ureter while it occurred in the renal pelvis in 65% of the general population (p = 0.0013). Similar numbers of high grade tumors were found in the Lynch syndrome and general populations (88% and 74%, respectively, p = 0.1108).
CONCLUSIONS: Upper urinary tract tumors develop at a younger age and are more likely to be in the ureter with an almost equal gender ratio in patients with Lynch syndrome.
It has high grade potential similar to that in the general population.
Menopause Symptoms Common After Gyn Cancer - Medpage (3/2010)
"However, Huang and colleagues found no studies in the medical literature documenting the frequency and nature of menopausal symptoms in gynecologic cancer survivors."
"Note that the percentage of gynecologic cancer survivors who reported menopausal symptoms was extremely high regardless of whether they received hormonal therapy."
Wednesday, April 06, 2011
Expression of DNA repair genes in ovarian cancer samples: Biological and clinical considerations
Abstract
The purpose of this study was to investigate retrospectively the mRNA expression of genes involved in different DNA repair pathways implicated in processing platinum-induced damage in 171 chemotherapy-naïve ovarian tumours and correlate the expression of the different genes with clinical parameters. The expression of genes involved in DNA repair pathways (PARP1, ERCC1, XPA, XPF, XPG, BRCA1, FANCA, FANCC, FANCD2, FANCF and PolEta), and in DNA damage transduction (Chk1 and Claspin) was measured by RT-PCR in 13 stage I borderline and 77 stage I and 88 III ovarian carcinomas.ERCC1, XPA, XPF and XPG genes were significantly less expressed in stage III than in stage I carcinoma; BRCA1, FANCA, FANCC, FANCD2 gene expressions were low in borderline tumours, higher in stage I carcinomas and lower in stage III samples. High levels of ERCC1, XPA, FANCC, XPG and PolEta correlated with an increase in Overall Survival (OS) and Progression Free Survival (PFS), whilst high BRCA1 levels were associated with PFS on univariate analysis.
With multivariate analyses no genes retained an association when adjusted by stage, grade and residual tumour. A tendency towards a better PFS was observed in patients with the highest level of ERCC1 and BRCA1 after platinum-based therapy than those given both platinum and taxol. The expression of DNA repair genes differed in borderline stage I, stage I and stage III ovarian carcinomas. The role of DNA repair genes in predicting the response in ovarian cancer patients seems far from being established.
blog: Taking a Stab at Cost-Effectiveness | Work In Progress
"....With an aim toward making some small step forward in that direction, Cohn et al tried analyzing the cost-effectiveness of Avastin in the treatment of ovarian cancer. (I know I’ve written about Avastin here before, and I don’t mean to pick on this drug, as if it is the richest child on the fancy pharmaceutical playground. This kind of analysis works well here because the high-priced drug acts almost like a caricature for cost considerations in general.)..."
Research Advocacy Network: 2010 Survey of Advocates Providing Results to Participants in Biospecimen Studies
Contents
Introduction
Overview of Advocate Survey
Survey Results
Summary and Conclusions
"Introduction
If you provided a biospecimen for research
purposes, would you want to know the
results of your individual tests? Would you
want these results only if they had health
implications? Who would you want to
provide you with these results – your
doctor? A genetic counselor? Someone else?..."
full free access: Proportion of second cancers attributable to radiotherapy treatment in adults: a cohort study in the US SEER cancer registries : The Lancet Oncology
Note: there is also chemotherapy-induced secondary cancers (not part of this study) but putting all treatment-related therapies (adverse events) in perspective
--------------------------------------------------------------------------------------------
Interpretation
A relatively small proportion of second cancers are related to radiotherapy in adults, suggesting that most are due to other factors, such as lifestyle or genetics.
Colonic stenting versus emergency surgery for acute left-sided malignant colonic obstruction: a multicentre randomised trial : The Lancet Oncology
Background
Colonic stenting as a bridge to elective surgery is an alternative for emergency surgery in patients with acute malignant colonic obstruction, but its benefits are uncertain.
We aimed to establish whether colonic stenting has better health outcomes than does emergency surgery.
We aimed to establish whether colonic stenting has better health outcomes than does emergency surgery.
Vitamin D and Prevention of Cancer — Ready for Prime Time? — NEJM
"Despite biologic plausibility and widespread enthusiasm, the IOM committee found that the evidence that vitamin D reduces cancer incidence and related mortality was inconsistent and inconclusive as to causality.
New trials assessing moderate-to-high-dose vitamin D supplementation for cancer prevention are in progress and should provide additional information within 5 to 6 years.
Although future research may demonstrate clear benefits of vitamin D related to cancer and other nonskeletal health outcomes, and possibly support higher intake requirements, the existing evidence falls short."
Apr 2011(pdf): Cost-Effectiveness of Genetic Screening for Lynch Syndrome (Available at obgmanagement.com)
Supported by
Myriad Genetics Laboratories, Inc
KEY POINTS
• Lynch syndrome is a hereditary predisposition to
colorectal and endometrial cancers (and other specific
malignancies), resulting from a gene mutation
• Lynch syndrome is the most common heritable cause
of colorectal cancer and endometrial cancer
• Practice guidelines limit risk assessment of Lynch syndrome
to 1) genetic testing in people in whom malignancies
have already developed and 2) mitigation of
the impact of disease by colonoscopic and endometrial
surveillance, and surgical prophylaxis
• No primary screening strategies currently exist for Lynch
syndrome
• Over 50% of women with Lynch syndrome who develop
two primary cancers develop a gynecologic cancer
before colon cancer
• Guidelines issued by ACOG recommend that ObGyns
incorporate identification and management of women
who have hereditary breast and ovarian cancer syndrome
into practice; similar guidelines do not exist for
Lynch syndrome
• A new and powerful study has established evidence for
a protocol of primary screening of Lynch syndrome at a
particular threshold of individual risk
• Specifically, primary screening for unaffected patients,
with risk assessment conducted beginning between
25 and 35 years of age, followed by genetic testing of
people whose risk exceeds 5%, has the potential to improve
health outcomes in a cost-effective way
Saturday, April 02, 2011
Guiding the guidelines : The Lancet
...Clinical Practice Guidelines We Can Trust is the tandem document from the IOM—tandem in the sense that one of these standards states that a systematic review must precede guideline formulation. The IOM points out that the database of the Guidelines International Network includes more than 3700 guidelines from 39 countries. The standards were formulated to overcome common deficiencies—particularly in bias and how bias is handled—in existing guidelines. These deficiencies include the variable quality of evidence, poorly done systematic reviews, methodology that is not transparent, a development group that does not reflect all stakeholders, and unmanaged conflicts of interest. The IOM recommends that before the development group is formed, conflicts of interest need to be fully disclosed—and their definition includes financial, intellectual, and institutional interests. The prospective panel members should also explain how any conflicts they might have could influence the guideline process. The IOM is clear in some specific areas: members of the group need to divest relevant financial investments they or family members hold, and not take part in advisory boards or marketing activities with relevant companies. Additionally, the chair and co-chairs should have no conflicts of interest, members with conflicts should form a minority, and funders should have no role in guideline development. Overall, tough talk from the IOM—but much needed talk. Apart from expert members in the group, the standards include involvement of patients or their representatives.
Thursday, March 31, 2011
My Sister's Voice (Canada) Lunafest - April 30th
For more information, visit us at lunafest.org
TICKET INFORMATION:
mysistersvoice@rogers.com
PHONE 905.666.3010
update for blog readers - newsreel
Newsreel section:
3 sections are now available for the newsreel section (latest news items)
scroll down to the newsreel section (see right hand side of blog) & then click on: ovarian cancer or BRCA or Lynch Syndrome
Wednesday, March 30, 2011
Lynch Syndrome Hereditary Cancers Public Awareness Day | Fight Colorectal Cancer
Increased Risk of Cancer
If a parent carries a Lynch mutation there is a 50-50 chance that their child will inherit Lynch syndrome with- 60 to 80 percent increased lifetime risk of colorectal cancer.
- 40 to 70 percent increased risk of endometrial cancer (cancer of the uterus lining).
- 13 percent increased risk for stomach cancer
- 12 percent increased risk of ovarian cancer.
- smaller, but significant risk of small intestine, urinary tract, heptobiliary (liver, gall bladder and bile ducts), skin, and brain cancers.
- Some families may also have increased risk for breast cancer.
Lynch Syndrome is also noted for multiple primary cancers (different cancers in one person)
medical news: Protection Against Cell Damage From Antioxidant Formula Prior To Radiation Exposure
"A unique formulation of antioxidants taken orally before imaging with ionizing radiation minimizes cell damage, noted researchers at the Society of Interventional Radiology's 36th Annual Scientific Meeting in Chicago, Ill. In what the researchers say is the first clinical trial of its kind, as much as a 50 percent reduction in DNA injury was observed after administering the formula prior to CT scans.
"In our initial small study, we found that pre-administering to patients a proprietary antioxidant formulation resulted in a notable dose-dependent reduction in DNA injury," said Kieran J. Murphy, M.D., FSIR, professor and vice chair, director of research and deputy chief of radiology at the University of Toronto and University Health Network, Toronto, Ontario, Canada. "This could play an important role in protecting adults and children who require imaging or a screening study," he added.
"Pre-administering this formula before a medical imaging exam may be one of the most important tools to provide radioprotection and especially important for patients in the getting CT scans," said Murphy. The study's data support the theory about a protective effect during these kinds of exposure, he explained....."cont'd
link to abstract:
"Purpose:
We examine use of the free radical scavengers vitamin C (VC), glutathione (GL) and uric acid (UA) as a pre-medication strategy prior to radiation exposures typical of medical imaging studies. Our intent was to develop a simple cocktail of antioxidants to be taken orally prior to X-Ray exposures that can protect a patient’s DNA against free radical mediated radiation injury"
link to meeting:
Why do People get Cancer? « Dr. Robert A. Nagourney – Rational Therapeutics – Blog discusses multiple primaries uterine/colon (Lynch Syndrome)
Note: the article lacks specific drug/chemotherapy intervention information which may be helpful to others
open access journal: Journal of Ovarian Research Differential hRad17 expression by histologic subtype of ovarian cancer
Background
In the search for unique ovarian cancer biomarkers, ovarian specific cDNA microarray analysis identified hRad17, a cell cycle checkpoint protein, as over-expressed in ovarian cancer. The aim of this study was to validate this expression.
Methods
Immunohistochemistry was performed on 72 serous, 19 endometrioid, 10 clear cell, and 6 mucinous ovarian cancers, 9 benign ovarian tumors, and 6 normal ovarian tissue sections using an anti-hRad17 antibody. Western blot analysis and quantitative PCR were performed using cell lysates and total RNA prepared from 17 ovarian cancer cell lines and 6 normal ovarian epithelial cell cultures (HOSE).
Results
Antibody staining confirmed upregulation of hRad17 in 49.5% of ovarian cancer cases. Immunohistochemistry demonstrated that only 42% of serous and 47% of endometrioid subtypes showed overexpression compared to 80% of clear cell and 100% of mucinous cancers.
Conclusions
hRad17 is over-expressed in ovarian cancer. This over-expression varies by subtype suggesting a role in the pathogenesis of these types. Functional studies are needed to determine the potential role of this protein in ovarian cancer.
REVIEW ARTICLE Online Open article: Biosimilar agents in oncology/haematology: from approval to practice
Abstract
The regulation of biosimilars is a process that is still developing. In Europe, guidance regarding the approval and use of biosimilars has evolved with the products under consideration. It is now more than 3 years since the first biosimilar agents in oncology support, erythropoiesis-stimulating agents, were approved in the EU. More recently, biosimilar granulocyte colony-stimulating factors have received marketing approval in Europe. This review considers general issues surrounding the introduction of biosimilars and highlights current specific issues pertinent to their use in clinical practice in oncology. Information on marketing approval, extrapolation, labelling, substitution, immunogenicity and traceability of each biosimilar product is important, especially in oncology where patients are treated in repeated therapy courses, often with complicated protocols, and where biosimilars are not used as a unique therapy for replacement of e.g. growth hormone or insulin. While future developments in the regulation of biosimilars will need to address multiple issues, in the interim physicians should remain aware of the inherent differences between biosimilar and innovator products.
Proportion of second cancers attributable to radiotherapy treatment in adults: a cohort study in the US SEER cancer registries : The Lancet Oncology
Blogger's Note: anticancer therapies also infer a risk of secondary cancers - treatment related secondary cancers - to put this in perspective
(U.S.) March 30th 2011 is Lynch Syndrome Hereditary Cancers Public Awareness Day - media
"State leaders, including the Governors of Oregon, Nevada, Arizona, Colorado, Missouri, Louisiana and Alabama, have joined a nationwide public awareness campaign by proclaiming March 30, 2011, Lynch Syndrome Hereditary Cancers Public Awareness Day....cont'd
full free access: Breast and Ovarian Cancer Risk due to Prevalence of BRCA1 and BRCA2 Variants in Pakistani Population: A Pakistani Database Report
Abstract
Pakistani population has a very rich anthrogeneological background with waves of migration from neighboring regions. Incidence rates of breast and ovarian cancer in Pakistan are on such a rapid rise that it is necessary to check the contributory factors, genetic and nongenetic. An insight into the prevalence data emphasizes the formulation of a BRCA1 and BRCA2 database for the Pakistani population.....
Most of BRCA1 and BRCA2 research has been focused on the Caucasian populations; however, the allelic frequency of higher penetrance genes in the Asian population may be higher than that in Caucasian population.................. cont'd (abstract/full free access)
see full paper for further information
examples: Figure 3 & 4: (brca 1/brca 2/specific mutations/variants):
abstract: DICER1 Mutations in Familial Multinodular Goiter (thyroid) With and Without Ovarian Sertoli-Leydig Cell Tumors
define:
multinodular goiter - A multinodular goiter is a thyroid gland that is usually enlarged and contains multiple thyroid nodules.
Pleuropulmonary blastoma (PPB) is a rare cancer originating in the lung or pleural cavity....
en.wikipedia.org/wiki/Pleuropulmonary_blastoma
multinodular goiter - A multinodular goiter is a thyroid gland that is usually enlarged and contains multiple thyroid nodules.
Pleuropulmonary blastoma (PPB) is a rare cancer originating in the lung or pleural cavity....
en.wikipedia.org/wiki/Pleuropulmonary_blastoma
---------------------------------------------------------------------------------------
Objective To determine whether familial MNG (multinodular goiter) with or without SLCT (Sertoli-Leydig cell tumor of the ovary) in the absence of PPB (pleuropulmonary blastoma) was associated with mutations in DICER1.
Conclusions DICER1 mutations are associated with both familial MNG and MNG with SLCT, independent of PPB. These germline DICER1 mutations are associated with dysregulation of miRNA expression patterns.
EvidenceUpdates - Interventions for preventing neuropathy caused by cisplatin and related compounds
BACKGROUND:
Cisplatin and several related antineoplastic agents used to treat many types of solid tumors are neurotoxic, and most patients completing a full course of cisplatin chemotherapy develop a clinically detectable sensory neuropathy. Effective neuroprotective therapies have been sought.
AUTHORS' CONCLUSIONS:
At present, the data are insufficient to conclude that any of the purported chemoprotective agents (acetylcysteine, amifostine, calcium and magnesium, diethyldithiocarbamate, glutathione, Org 2766, oxycarbazepine, or Vitamin E) prevent or limit the neurotoxicity of platin drugs among human patients.
EvidenceUpdates: Interventions to enhance return-to-work for cancer patients. Cochrane Database Systematic Rev. 2011
Cancer survivors are 1.4 times more likely to be unemployed than healthy people. It is therefore important to provide cancer patients with programmes to support the return-to-work process.
OBJECTIVES: To evaluate the effectiveness of interventions aimed at enhancing return-to-work in cancer patients.
| link - updated Comments from Clinical Raters |
|---|
Tuesday, March 29, 2011
Doctor and Patient: Interns at the Operating Table - NYTimes.com
included in the article:
This month The Journal of the American College of Surgeons published the results of a study on how well patients come through when a surgeon-in-training is involved in the operation.
(STUDY DESIGN:
We identified 607,683 surgical cases from 234 hospitals from the 2006 to 2009 American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP). Outcomes were compared by resident involvement for all general and vascular cases as well as for specific general surgical procedures.)Surgeons' and residents' double-gloving practices at 2 teaching hospitals in Ontario (patient safety/injury)
".......Of the 77% who reported at least 1 injury/year, 67% stated that they had not reported it to an employee health service.
Background: Surgeons and residents are at increased risk of exposure to blood-borne pathogens owing to percutaneous injury (PI) and contamination. One method known to reduce risk is double-gloving (DG) during surgery.
Conclusion: Percutaneous injuries occur frequently during surgery, yet routine DG (double gloved), an effective means of reducing risk, was carried out by less than half of the surgeons and residents participating in this study. This highlights the need for a more concerted and broad-based approach to increase the use of a measure that is effective, inexpensive and easily carried out."
Canadian Journal of Surgery Editorial: The continuing challenge of surgical access
"........Perhaps a wider range of
skills would provide new surgeons with a buffer, helping
them to work within a resource-constrained system. The
idea that “you get to know so much about 1 thing that
pretty soon you know little about everything” haunts surgeons
who limit their skill sets...."
(U.S.) Health Alert: Disease Clusters Spotlight the Need to Protect People from Toxic Chemicals
Note:
1) search terms of 'ovarian'; 'gynecologic' & 'female reproductive' produced zero results;2) states included in report: Arkansas, California, Delaware, Florida, Louisiana, Michigan, Missouri, Montana, North Carolina, Ohio, Pennsylvania, Tennessee, Texas
About NRDC
The Natural Resources Defense Council (NRDC) is an international nonprofit environmental organization with
more than 1.3 million members and online activists. www.nrdc.org.
Cancer Clusters,
Disease, and the need to Protect
People from Toxic Chemicals
An unusually large number of people sickened by a disease in a certain place and
time is known as a ‘disease cluster’. Clusters of cancer, birth defects, and other
chronic illnesses have sometimes been linked to chemicals or other toxic pollutants
in local communities, although these links can be controversial. There is a need for
better documentation and investigation of disease clusters to identify and address
possible causes. Meanwhile, toxic chemicals should be identified and controlled
through reform of the Toxic Substances Control Act, so these chemicals don’t
pollute communities and sicken people.
full free access: Subtype-specific mutation of PPP2R1A in endometrial and ovarian carcinomas - Journal of Pathology
Abstract
PPP2R1A mutations have recently been described in 3/42 (7%) of clear cell carcinomas of the ovary. ...............This putative tumour suppressor complex is involved in growth and survival pathways. Through targeted sequencing of PPP2R1A, we identified somatic missense mutations in 40.8% (20/49) of high-grade serous endometrial tumours, and 5.0% (3/60) of endometrial endometrioid carcinomas. Mutations were also identified in ovarian tumours at lower frequencies: 12.2% (5/41) of endometrioid and 4.1% (2/49) of clear cell carcinomas. No mutations were found in 50 high-grade and 12 low-grade serous carcinomas. Amino acid residues affected by these mutations are highly conserved across species and are involved in direct interactions with regulatory B-subunits of the PP2A holoenzyme. PPP2R1A mutations in endometrial high-grade serous carcinomas are a frequent and potentially targetable feature of this disease. The finding of frequent PPP2R1A mutations in high-grade serous carcinoma of the endometrium but not in high-grade serous carcinoma of the ovary provides clear genetic evidence that these are distinct diseasesMonday, March 28, 2011
Charities Listings (ovarian cancer) Canada - government of Canada website including tax return information
Canada Revenue Agency
www.cra.gc.ca
Basic Search Results
Statistics and data on the Charities and Giving Web pages are compiled by the Charities Directorate of the Canada Revenue Agency (CRA) for the sole purpose of providing the public with direct access to information about charities in Canada.The CRA is not responsible for the use and manipulation by any persons of this information.
Charity Status: Canadian Registered Charities
Charity Name: ovarian cancer
A search using the information shown above gave this result:
5 matches found.
5 matches found.
Charity Name: FONDATION DU CANCER HEREDITAIRE DU SEIN ET DES OVAIRES/HEREDITARY BREAST AND OVARIAN CANCER FOUNDATION / 883465304RR0001
Charity Status: Registered
Effective Date of Status: 2003-10-15
Sanction: N/A
Address: 5791 FERNCROFT ROAD
City: HAMPSTEAD Province/Territory/Other: QUEBEC Country: CA
Postal Code/Zip Code: H3X1C6
Charity Type: Health
Category: Services Other Than Hospitals
Charity Status: Registered
Effective Date of Status: 2005-01-01
Sanction: N/A
Address: 114 11728 KINGSWAY AVE
City: EDMONTON Province/Territory/Other: ALBERTA Country: CA
Postal Code/Zip Code: T5G0X5
Charity Type: Health
Category: Services Other Than Hospitals
Charity Status: Registered
Effective Date of Status: 2010-01-01
Sanction: N/A
Address: 700-1914 HAMILTON ST
City: REGINA Province/Territory/Other: SASKATCHEWAN Country: CA
Postal Code/Zip Code: S4P3N6
Charity Type: Health
Category: Services Other Than Hospitals
Charity Status: Registered
Effective Date of Status: 1998-08-01
Sanction: N/A
Address: 145 FRONT ST EAST SUITE 101
City: TORONTO Province/Territory/Other: ONTARIO Country: CA
Postal Code/Zip Code: M5A1E3
Charity Type: Health
Category: Services Other Than Hospitals
Information Return: T3010 Return
direct link - compensation section
direct link - compensation section
| What was the charity's total expenditure on all compensation in the fiscal period? | $ 1,420,438 |
Charity Status: Registered
Effective Date of Status: 2000-08-11
Sanction: N/A
Address: 74 MUZICH PLACE
City: WOOBRIDGE Province/Territory/Other: ONTARIO Country: CA
Postal Code/Zip Code: L4L9C5
Charity Type: Health
Category: Services Other Than Hospitals
Information Return: T3010 Return
Blog: Our Cancer — "It’s NOT Easy to Go There.." Laurie Singer Sievers
"....What about all of us who are carrying around the baggage of the disease? It's real and if you ask me, it's an epidemic."
Treating Depression with Anti-Inflammatory Agents > CMELLC - Life Long Learning > Treating the Whole Patient
Note: interesting discussion regarding aspirin (anti-inflammatory) and depression
Expert Review - slides: Renal Cell Carcinoma Biology and the Rationale for VEGF (sorafenib, sunitinib, erlotinib, avastin, interleukins, etc)
| Note: if you are unable to access this slide presentation it is because you need to register on the site (free); it may be of interest to those with clear cell ovarian cancer; the largest % of renal cancers are of the clear cell subtype (a known ~75%) ------------------------------------------------------------------------------------------------------- MODULE 1: Renal Cell Carcinoma Biology and Rationale for VEGF Expert review with Lee Lokey, MD, and Brian I. Rini, MD, focusing on renal cell carcinoma | |||
| Discussant: | Brian I. Rini, MD—Cleveland Clinic Taussig Cancer Institute, Cleveland, Ohio, United States | ||
| Interviewed by: | Lee Lokey, MD—prIME Oncology, Atlanta, Georgia, United States | ||
published March 21st: Wait Times in Canada--A Comparison by Province
click here for the pdf file
Conclusion
Although there is still much we don’t know, today the picture of wait times across priority areas and provinces is more complete and comparable than in the past. All-Canada estimates indicate that 8 out of 10 patients across the country receive priority procedures (hip, knee, hip fracture repair, cataract and bypass
surgery and radiation treatment) within the time frames that clinical evidence shows is appropriate. That said, the likelihood of receiving treatment within these time frames varies considerably, depending on both the priority area and where one lives in Canada. While there have been some improvements in wait times for priority area procedures over the last three years, these improvements are not being seen consistently across
all procedures or across all provinces. The ability to report these important findings has been enabled by provincial collaboration on measuring and collecting data. Important steps remain in improving consistency of cardiac urgency levels, as well as building more comprehensive diagnostic imaging data before the wait time information can be assessed in a more meaningful way."
Sunday, March 27, 2011
Saturday, March 26, 2011
Risk assessment for recurrent venous thrombosis – The Lancet (as it applies to transdermal oestrogens)
Note: author's response to commentaries on the original research article, links included to the discussion
The case for a global rare-diseases registry : The Lancet
The case for a global rare-diseases registry
Rare diseases are a clinically heterogeneous group of about 6500 disorders,1 and in fewer than 200 000 individuals in the USA.2 They are commonly diagnosed during childhood, often inherited, and can have deleterious long-term effects. Although any one condition is rare, their cumulative public health burden is substantial, with 6—8% of people having a rare disease at some point during life.3
Because of the rarity, no single institution, and in many cases no single country, has sufficient numbers of patients to do generalisable clinical and translational research. Geographic spread of patients has been a major impediment to recruitment into clinical trials....cont'd
Friday, March 25, 2011
Thursday, March 24, 2011
worth reading especially the viewpoint: 2 items: editorial (patient consent/genetics) + viewpoint (breaching patient privacy)
Rapid Online Publications Editorial
Alerting genetic relatives to a risk of serious inherited disease without a patient’s consent Graeme K Suthers, Elizabeth A McCusker and Samantha A Wake MJA Rapid Online Publication — 24 March 2011 http://www.mja.com.au/public/issues/194_11_060611/sut11435_fm.html Viewpoint (blogger's opinion - excellent article) Doctors breaching patient privacy: Orwell redux David J Handelsman, Leo A Turner and Ann J Conway MJA Rapid Online Publication — 24 March 2011 http://www.mja.com.au/public/issues/194_11_060611/han10307_fm.html
full free access: Malignant bowel obstruction: Individualized treatment near the end of life
Key points
Combinations of analgesics, antisecretory drugs, and antiemetics can provide acceptable symptom relief.
A venting gastrostomy should be considered if drug therapy fails to reduce nausea and vomiting to an acceptable level.
A nasogastric tube should be used only as a temporizing measure, until symptoms are controlled medically or a venting gastrostomy is placed.
Total parenteral nutrition is beneficial only in patients with intermediate life expectancy who may otherwise die of starvation rather than the cancer itself.
Will Open Government make Canada's health agencies more transparent? -- Canadian Medical Association Journal
"But secrecy and lack of public involvement undermine accountability and the credibility of public institutions and their decisions. They diminish
public trust and feed conspiracy theories."
Prognostic Significance of Splenectomy as Part of Initial Cytoreductive Surgery in Ovarian Cancer
Note: a similar paper regarding splenectomy - posted on this blog Sept 6, 2010
PURPOSE:
We sought to examine how splenectomy as part of up-front cytoreductive surgery in ovarian cancer influences the postoperative course and affects survival.
CONCLUSIONS:
The addition of splenectomy to up-front cytoreductive surgery was feasible and safe. However, it appears to carry with it a shortened survival that is unrelated to postoperative morbidity. Our data raise the questions that splenectomy is needed for optimal cytoreduction in more biologically aggressive disease and that splenectomy may be an independent prognostic factor related to depressed immune function.
No benefit from combining HE4 and CA125 as ovarian tumor markers in a clinical setting
of interest: "HE4 was not elevated in endometriosis"
CONCLUSIONS:
The major advantage of HE4 lies in its specificity and improved detection of borderline tumors and early stage ovarian and tubal cancers. HE4 is superior to CA125 with or without RMI and ROMA indices. However, we see no benefit from combining both markers in clinical practice.
Adequacy of risk-reducing gynaecologic surgery in BRCA1 or BRCA2 mutation carriers and other women at high risk of pelvic serous cancer
"...Four serous ovarian cancers and one endometrioid endometrial cancer were detected during surgery or pathological examination.
In conclusion Australasian women attending a specialist gynaecologic oncologist for RRGS (risk reducing gynaecologic surgery) are most likely to have adequate surgery and pathological examination.
Additional education of clinicians and consumers is needed to ensure optimal surgery and pathology in these women."
Improved 5-year disease-free survival for FIGO stage I epithelial ovarian cancer patients without tumor rupture during surgery
Abstract
Objective.
To investigate the impact of perioperative capsule rupture on disease-free survival (DFS) and cancer-specific survival (CSS) in patients with FIGO stage I epithelial ovarian cancer (EOC I).Methods.
This prospective population-based study enrolled all 279 patients with EOC I diagnosed in Norway between 2002 and 2004. All patients underwent primary surgery. The data were collected from notification reports to the Norwegian Cancer Registry and included medical, surgical and histopathological records. Kaplan–Meier plots were used to show differences in DFS and CSS. Cox regression analyses were used to show the effect of prognostic factors on survival, expressed as hazard ratios (HRs).Results.
Significantly more patients in the capsule rupture group (Cr group) had clear cell tumors (28%) than in the FIGO stage IA and IB (AB group: 14%) groups, and the FIGO stage IC (C group: 17%; p < 0.05) group. Despite adjuvant chemotherapy (AC), these patients had a poor 5-year DFS, 94% in the non-AC group and 81% in the AC group (p < 0.01).After five years of follow-up, there was a lower DFS among patients in the Cr group (79%) and the C group (81%), compared with patients in the AB group (91%; p < 0.05). Independent prognostic factors at the time of diagnosis were grade, histological type, ascites, adhesions, performance status, CA125 and DNA ploidy.
After correcting for the four most important prognostic factors (grade, histological type, ascites, and DNA ploidy), the HR for recurrence was 4.0 (95% CI 1.3–12.7; p < 0.05) for the Cr group and 1.8 (95% CI 0.5–6.1; p = 0.3) for the C group, compared with the AB group.
Conclusions.
Improvement was observed in the 5-year DFS for EOC I patients without tumor rupture during surgery compared with those with tumor rupture. Since AC did not improve the long-term DFS and CSS rates, it is of utmost importance that surgeons avoid tumor rupture during surgery.Research Highlights
► Impact of perioperative capsule rupture on DFS and CSS in stage I epithelial ovarian cancer.► The study was prospective and population-based.
► Stage I epithelial ovarian cancer without tumor rupture during surgery has improved at the 5-year DFS.
(U.S.) Patient Advocate Foundation :: 1-800-532-5274
Patient Services
Our professional staff members intervene by making conference calls when needed, assisting with appeals to insurance
companies or the Social Security Administration, negotiating with providers in medical debt situations or securing access to care.
Our staff strive for positive resolutions whenever possible.
Wednesday, March 23, 2011
Women's Health - Full Text: Preventing familial breast and ovarian cancer: major research advances with little implication
Preventing familial breast and ovarian cancer: major research advances with little implication
Primary prevention of hereditary breast–ovarian cancer syndrome, which accounts for 5–10% of all breast cancer diagnosis, represents a prime paradigm of excellence of personalized medicine [1,2]. However, genetic testing can reveal that BRCA mutation carriers account for less than 25% of the familial risk. There has been little progress in explaining the missing heritability of the remaining 75% of women with family history who test negative for BRCA mutations. Neither recently identified common low-penetrance variants alone, nor their interactions with established environmental risk factors, are able to explain missing heritability. But even among BRCA mutation carriers, the decision by an expert scientific team for the optimal preventive strategy, choosing between prophylactic surgery and intensive surveillance, is very difficult and should be individualized for each woman. Here we discuss the latest advances in breast cancer genetics, their potential to impact prevention strategies and practices, and the future perspectives for a true personalized preventive medicine...........
| Missing heritability |  |   |
|---|
Previous work has suggested the polygenic model to help understand the 75% of breast cancer familial risk [6]. According to this model, the missing heritability could be explained by the accumulation of low to moderate genetic risk variants other than BRCA1/2 genes, namely BRCA3 or BRCA4 high-penetrance genes. Indeed, more than 15 years after the discovery of BRCA1/2 genes, the ‘classical’ linkage studies in high-risk families have identified no other high-penetrance genes. The completion of the HapMap 3 project with a database of common and rare variants [7] and high-throughput screening technology has allowed a new generation of association studies to provide improved understanding of the genetics of familial cancer.
(worth reading) Editorial: The Values and Value of Patient-Centered Care -- Epstein and Street 9 (2): 100 -- Annals of Family Medicine
"The originators of client-centered and patient-centered health care were well aware of the moral implications of their work, which was based on deep respect for patients as unique living beings, and the obligation to care for them on their terms. Thus, patients are known as persons in context of their own social worlds, listened to, informed, respected, and involved in their care—and their wishes are honored (but not mindlessly enacted) during their health care journey.2–6 There have been concerns that patient-centered care, with its focus on individual needs, might be at odds with an evidence-based approach, which tends to focus on populations. Fortunately, that debate has been laid to rest; proponents of evidence-based medicine now accept that a good outcome must be defined in terms of what is meaningful and valuable to the individual patient.7 Patient-centered care, as does evidence-based medicine, considers both the art of generalizations and the science of particulars.8"
Cochrane Review: abstract - Chemotherapy for malignant germ cell ovarian cancer [Cochrane Database Syst Rev. 2011] - PubMed result
AUTHORS' CONCLUSIONS:
We found only low quality evidence on the use of chemotherapy in malignant germ cell tumours of the ovaries. Therefore we are unable to reach definite conclusions about the relative benefits and harms of chemotherapy use in this disease regardless of disease stage. Due to the benefit of chemotherapy in germ cell cancer of the testis, a trial of chemotherapy versus best supportive care is unlikely to be feasible. Despite this, good quality randomised studies are warranted in this disease to define the role of chemotherapy (type of chemotherapy, duration of treatment, benefit, short and long term toxicities). Given the rarity of this disease, we feel a trans-global approach would be essential in order to perform such trials.
alternate source including professional commentary (gynecologic oncology) link
full free access: (references Dr Folkman 1971) Antiangiogenic Therapies in Epithelial Ovarian Cancer (printer-friendly)
Source: Posted: 03/22/2011; Cancer Control. 2011;18(1):31-43. © 2011 H. Lee Moffitt Cancer Center and Research Institute, Inc.
PLOS Medicine: Promotional Tone in Reviews of Menopausal Hormone Therapy After the Women's Health Initiative: An Analysis of Published Articles
View and Join Ongoing Discussions
Original Article Promotional Tone in Reviews of Menopausal Hormone Therapy After the Women's Health Initiative: An Analysis of Published Articles
| 0 responses | Promotional Tones - Hormone Therapy after WHI | Posted by sandipniauskas on 23 Mar 2011 at 08:32 GMT |
| Most recent response on 23 Mar 2011 at 08:32 GMT | ||
| 2 responses | Pfizer Comment | Posted by cloder on 17 Mar 2011 at 17:54 GMT |
| Most recent response on 22 Mar 2011 at 20:50 GMT | ||
| 1 response | Money isn't enough | Posted by lexchin on 16 Mar 2011 at 16:55 GMT |
| Most recent response on 17 Mar 2011 at 14:27 GMT | ||
| 0 responses | Follow the money... | Posted by EthicalNag on 16 Mar 2011 at 14:40 GMT |
| Most recent response on 16 Mar 2011 at 14:40 GMT | ||
Tuesday, March 22, 2011
Progress Being Made in Genome Sequencing - Medscape interview (in research)
Note: the specific references in this article are colorectal cancer but of interest (re: metastases)
full free access: PROTECT study - Dalteparin versus Unfractionated Heparin in Critically Ill Patients — NEJM (venous thromboembolism-blood clots)
"Venous thromboembolism is an important complication of critical illness.....cont'd
The PROTECT Investigators for the Canadian Critical Care Trials Group and the Australian and New Zealand Intensive Care Society Clinical Trials Group
Methods - Study Design
The trial was conducted in 67 ICUs in academic and community hospitals in Canada, Australia, Brazil, Saudi Arabia, the United States, and the United Kingdom. Recruitment began in May 2006 and, as projected, was completed in 4 years. The trial protocol is available with the full text of this article at NEJM.org.7
abstract: Healthy eating index and ovarian cancer risk - Cancer Causes and Control
Abstract
The evidence for a role of diet on ovarian cancer prevention remains inconclusive. While many studies have evaluated individual foods and food groups, the evaluation of a comprehensive dietary quality index for predicting cancer risk has received little attention. This study investigates the association between the Healthy Eating Index (HEI), which reflects adherence to the current USDA Dietary Guidelines for Americans and ovarian cancer risk in a population-based case–control study in New Jersey. A total of 205 cases and 390 controls completed the Block 98.2 food frequency questionnaire (FFQ) in addition to reporting on potential risk factors for ovarian cancer. FFQ data were then utilized to calculate the HEI score, and cup, ounce, gram, or caloric equivalents for the 12 different food groups comprising the index. In multivariate models, the OR (overall risk) for the highest tertile of the HEI score compared with the lowest (reflecting a better diet compared with a worse diet) was 0.90 (95% CI: 0.55–1.47).
There was limited evidence for a statistically significant association between any of the 12 individual food components and ovarian cancer risk. Based on this study’s results, neither individual food groups nor dietary quality showed potential for preventing ovarian cancer.
There was limited evidence for a statistically significant association between any of the 12 individual food components and ovarian cancer risk. Based on this study’s results, neither individual food groups nor dietary quality showed potential for preventing ovarian cancer.
abstract: Genital powder exposure and the risk of epithelial ovarian cancer Cancer Causes and Control, Online First™
Conclusions
The International Agency for Research on Cancer has designated perineal exposure to talc (via the application of genital powders) as a possible carcinogen in women. A modest association of ovarian cancer with this exposure was seen in our study and in some previous ones, but that association generally has not been consistent within or among studies. Therefore, no stronger adjective than “possible” appears warranted at this time.
Subscribe to:
Posts
(
Atom
)
