Medical News: Statins Up Diabetes Risk in Older Women - in Primary Care, Diabetes from MedPage Today (2nd article)

Action Points

---

• This study found that older women who take statins may be at an increased risk for developing type 2 diabetes.
• Note that the risk was seen with all types of statins.

"Older women who take statins may be at an increased risk for developing type 2 diabetes, researchers found.

In an analysis of data from the Women's Health Initiative, postmenopausal women who were on a statin at study entry had almost a 50% greater risk of diabetes than those who weren't on the cholesterol-lowering drugs, Yunsheng Ma, MD, PhD, of the University of Massachusetts School of Medicine, and colleagues reported online in the Archives of Internal Medicine.

"This study urges us to further evaluate the risk-benefit profile of statins," Ma told MedPage Today, adding that the ratio will likely vary by patient population....."

Picture Your Life After Cancer - Interactive Feature - NYTimes.com

Picture Your Life After Cancer

For the estimated 12 million cancer survivors in the U.S., some of life's biggest challenges and successes begin after treatment ends. Here are your photos and insights about life after cancer. (Join the discussion here.)

Add your photo to the collage here.

webinar - Wed Jan 11th - 2011 Commonwealth Fund International Health Policy Survey of Sicker Adults

Date:	Wed, Jan 11, 2012
Time:	11:30 AM EST
Duration:	1 hour 30 minutes
Host(s):	Christine Haran

 2011 Commonwealth Fund International Health Policy Survey of Sicker Adults

Please register for this meeting.

Meeting Description:

This webinar will examine the findings of the latest International Health Policy Survey of Sicker Adults in Eleven Countries, conducted in Australia, Canada, France, Germany, the Netherlands, New Zealand, Norway, Sweden, Switzerland, the United Kingdom, and the U.S.    Published in November, the study compared the experiences of adults with complex care needs on financial barriers to care, access to care, care coordination, preventive care, and support for self-management.    International respondents from England, Switzerland, and the Netherlands will comment on survey findings.

Multinational Comparisons of Health Systems Data, 2011 - The Commonwealth Fund including link to 2011 patient care coordination (11 countries)

"International comparisons of health care systems offer valuable tools to health ministers, policymakers, and academics wishing to evaluate the performance of their country's system. In this chartbook, we use data collected by the Organization for Economic Cooperation and Development (OECD) to compare health care systems and performance on a range of topics, including spending, hospitals, physicians, pharmaceuticals, prevention, mortality, quality of care, and prices. We present data across several industrialized countries: Australia, Canada, Denmark, France, Germany, Japan, the Netherlands, New Zealand, Norway, Sweden, Switzerland, the United Kingdom, and the United States. Whenever possible, we also present the median value of all 34 members of the OECD.......

Downloads

• Chartbook (248K PDF)
• • Chartbook (626K PPT) 

    Related

    • In the Literature
      • New 2011 Survey of Patients with Complex Care Needs in Eleven Countries Finds That Care Is Often Poorly Coordinated

message from David Haas ' Networks That Support Cancer Patients

Blogger's Note: please respond directly to David

Networks That Support Cancer Patients

Receiving a cancer diagnosis is a frightening and life-changing event. It brings worries about treatment and fear of dying, as well as how to keep spirits up during the darkest days. There are many things to consider, big decisions to be made and emotions can be overwhelming. This where cancer support networks come in.

A support network is made up of people who have gone through the cancer experience and can lend their own unique perspective, in the hope of helping others. The groups meet in hospitals, libraries, in church or other public spaces and are led by doctors, social workers and psychologists who understand the challenges of cancer, from breast cancer to mesothelioma.

Face to face groups offer an intimate atmosphere of sharing and social activities, as well as love and understanding. It is in these support networks that the many different faces of cancer can be seen clearly and stories of survival can be heard. Sometimes all a patient needs for encouragement is to know they are not alone.

Cancer support networks can be found on the Internet, as well. This type of group is suited for those who are too ill to attend a public get together, or wish to talk about their experience anonymously. Online support often encourages a larger degree of sharing, as there is no pressure of speaking in front of a live group or fear of judgment over physical weakness and a loss of looks.

Regardless of the type of network a patient participates in, it is the emotional support that matters, as this is just as important as the medical treatment itself. Maintaining a positive outlook and eliminating feelings of isolation can go a long way toward promoting remission of the disease.

Any cancer patient who wishes to take part in a support network can ask their doctor, social worker or simply do a search online. Most patients are recommended to join a support group as a regular part of their treatment.

Cancer is not a death sentence. It is a chance to regain perspective and begin life again from a new place. 

By David Haas

WEBMD: Statins May Raise Diabetes Risk in Older Women (short and longterm use)

open access: Molecular Cancer | Role of Bcl-3 in solid tumors

"In this regard, it is interesting that, in addition to the known deregulation in leukemias and lymphomas, genome-wide expression studies have shown that Bcl-3 is overexpressed in breast cancer, glioblastoma tumors, ovarian cancer and, intriguingly, teratomas and embryonal> carcinomas (additional file 2). Although not validated, these results support the potential importance of this oncogene in a variety of tumors."

Role of Bcl-3 in solid tumors

Vilma Maldonado and Jorge Melendez-Zajgla

Molecular Cancer 2011, 10:152 doi:10.1186/1476-4598-10-152
Published: 23 December 2011

Abstract (provisional)

Bcl-3 is an established oncogene in hematologic malignancies, such as B-cell chronic lymphocytic leukemias. Nevertheless, recent research has shown that it also participates in progression of diverse solid tumors. The present review summarizes the current knowledge of Bcl3 role in solid tumors progression, including some new insights in its possible molecular mechanisms of action

The complete article is available as a provisional PDF. The fully formatted PDF and HTML versions are in production.

open access: Whole Genome Sequences of a Male and Female Supercentenarian, Ages Greater than 114 Years | Frontiers in Genetics of Aging

Why Some People Live to 110 - Drugs.com MedNews

"......In what they describe as a first-of-a-kind study, the researchers analyzed the whole genome sequences of a man and a woman who lived past the age of 114 and found that they had as many disease-associated genes as other people.
For example, the man had 37 genetic mutations associated with increased risk for colon cancer....."

Jan 8th - Novartis Consumer Health Inc. Issues Voluntary Nationwide Recall of Certain Over-the-Counter Products... -- Excedrin, NoDoz, Bufferin, Gas-X Prevention

PARSIPPANY, N.J., Jan. 8, 2012 /PRNewswire/ -- Novartis Consumer Health, Inc. (NCH) announced today that it is voluntarily recalling all lots of select bottle packaging configurations of Excedrin^® and NoDoz^® products with expiry dates of December 20, 2014 or earlier as well as Bufferin^® and Gas-X Prevention^® products with expiry dates of December 20, 2013 or earlier, in the United States. NCH is taking this action as a precautionary measure because the products may contain stray tablets, capsules, or caplets from other Novartis products, or contain broken or chipped tablets...........

open access Frontiers | Epigenomics of Ovarian Cancer and Its Chemoprevention | Frontiers in Epigenomics

.......Due to the atypical syndrome of the early stage of ovarian cancer, it is difficult to diagnose in its early stages. By the time most ovarian cancers are diagnosed, they are already at stage III or IV. The two most significant obstacles to the effective treatment of ovarian cancers are the lack of early diagnostic markers and the development of drug resistance after therapeutic treatment of advanced disease. Ovarian cancer screening with transvaginal ultrasound (TVU) and CA125 was evaluated in the Prostate, Lung, Colorectal, and Ovarian (PLCO) trial, however, it was revealed that the predictive value of both tests was relatively low (Buys et al., 2005). Increasing evidence indicates that epigenetic mechanisms may play a major role in the development of ovarian cancer..........
In this analysis, we will evaluate the current status of epigenomics of ovarian cancer and will include epigenetic mechanisms involved in ovarian cancer development such as DNA methylation, histone modifications, and non-coding microRNA. Development of biomarkers, the epigenetic basis for drug resistance and improved chemotherapy for ovarian cancer will also be assessed. In addition, the potential use of natural compounds as epigenetic modulators in chemotherapy shows promise in moving to the forefront of ovarian cancer treatment strategies........

open access journal: Frontiers | Grand Challenges in Oncology | Frontiers in Oncology

Frontiers in Oncology

This new open access journal has one of the major goals to be the forum for publications in the most important areas of cancer research, spanning from diagnosis, and prevention to treatment of early and advanced cancer and drug development, to the most cutting edge technologies that can be implemented to study cancer and improve its treatment. The fast pace of research and its ever increasing scope and breath, require a comprehensive forum that allows both the depth of research and a broad readership. This will be accomplished by a large series of subspecialties within Frontiers in Oncology, which span the major areas of disease-oriented research, epidemiology and prevention, treatment, and basic research.

open access: A person-time analysis of hospital activity among cancer survivors in England - UKPMC Article - UK PubMed Central

Conclusion:

The person-time approach used in this study is more revealing than a simple enumeration of cancer survivors and hospital admissions. Hospital activity among cancer survivors is highest soon after diagnosis. The effect of age on the amount of hospital activity is different for each type of cancer.

...........This paper highlights the significant effect that time since diagnosis has on the average amount of hospitalisation experienced by cancer survivors. The majority of cancer-related admitted hospital episodes of care occurred in the first year following diagnosis (when initial cancer treatment takes place); however, there was also a significant amount of hospital activity in the period 1–5 years after diagnosis, particularly among survivors of colorectal and lung cancers, which is indicative of the ongoing consequences of cancer and its treatment. Other work has shown that the final year before death also contains significant amounts of hospitalisation of cancer survivors (Maddams et al, 2011). These findings help to understand the burden of cancer on the health service, but further work is still required to identify potential areas of unmet needs among cancer survivors.

open access: Fruit and vegetables and cancer risk - UKPMC Article - UK PubMed Central

Blogger's note: the article/reference(s) does not include ovarian cancer research on this issue

The possibility that fruit and vegetables may help to reduce the risk of cancer has been studied for over 30 years, but no protective effects have been firmly established..........

blog: An Update to 23andMe Customers

open access: As-Needed Morphine: Yes, but at What Dose and at What Interval?

..........Given the above-illustrated opinion conflicts, with a 10-fold variation in dose and a six-fold variation in timing interval, a search through published sources was conducted, mirroring a wide range of combinations regarding recommendations for both the PRN narcotic doses and the appropriate intervals at which they should be repeated in the event of continued pain. Data from 22 review articles and texts that review guidelines for the treatment of cancer pain, presented in Table 3, ^1-22 provided a 20-fold variation in recommended narcotic doses (1% to 20% of daily doses) along with scattered opinions, or no direction, regarding appropriate dose intervals for potential repeat doses...............

.............Specific guidelines for prescribing opioids are needed to allow practitioners to feel comfortable in administering these medications. These guidelines must include how to determine the appropriate dose for breakthrough pain, and the appropriate and safe interval that will allow for rapid pain relief, but maintain patient safety. On completion of this project, the 2004 National Comprehensive Cancer Network guidelines for cancer pain were found.²⁷ These guidelines come to similar conclusions that recommend the use of intravenous narcotic doses of 10% to 20% of the daily intravenous morphine equivalent and the use of repeat doses at 15-minute intervals, if pain is still present. The information from this project might be used to facilitate continuous-improvement projects at individual institutions. Such a project is in process locally. The incorporation of this new information regarding PRN narcotic use should better serve the needs of patients.

Toward a Better Dialogue Between Neuro-Oncologists and Phase I Investigators

pdf file

open access: Letter: Survival Is Not a Good Outcome for Randomized Trials With Effective Subsequent Therapies

Link to Letter

 REFERENCES (original article)

1. ↵
   1. Korn EL,
   2. Freidlin B,
   3. Abrams JS

   (2011) Overall survival as the outcome for randomized clinical trials with effective subsequent therapies. J Clin Oncol 29:2439–2442.

   Abstract/FREE Full Text

When a Decision Must Be Made: Role of Computer Modeling in Clinical Cancer Research

Every day, multidisciplinary oncology teams make dozens of treatment decisions that may have a tremendous impact on a patient's survival and quality of life. Made with the best of intentions, these decisions are informed by basic science and clinical research findings, clinical experience, and health policy. All too often, results from the gold standard of clinical trial research, a randomized controlled trial (RCT), that fit the specific details of the patient's situation are not available to guide these decisions...........

open accerss: Exposure–response relationship of AMG 386 in combination with weekly paclitaxel in recurrent ovarian cancer and its implication for dose selection

Abstract

Purpose  

To characterize exposure–response relationships of AMG 386 in a phase 2 study in advanced ovarian cancer for the facilitation of dose selection in future studies. 

 .....AMG 386 (previously referred to as 2xCon4) is an investigational peptide-Fc fusion protein that mediates antiangiogenic effects by potently and selectively inhibiting the interaction of angiopoietin-1 and angiopoietin-2 with Tie2 [16]. Primary endpoint results from a phase 2 study of AMG 386 in combination with weekly paclitaxel for the treatment of recurrent ovarian cancer showed longer median progression-free survival (PFS) for patients receiving AMG 386 at 10 and 3 mg/kg once weekly (QW), compared with placebo (the data are described in the primary analysis [17]). Additional dose-exposure analyses suggested a dose–response effect across treatment arms......

Blogger's Note: stats removed for ease of reading (eg. CI):

Progression-free survival (the primary endpoint) in the phase 2 study was 7.2 months in the AMG 386 10 mg/kg QW dose group and 5.7 months  in the 3 mg/kg group, compared with 4.6 months for placebo. Results from Tarone’s test and dose-exposure analyses suggested a dose–response effect for PFS across the three arms.... 

Consumer Updates > FDA Warns About Stem Cell Claims

On this page 

• Regulation of Stem Cells
• Advice for Consumers
• Thwarting a Stem Cell Scheme

not yet recruiting: Integrated Molecular Profiling in Advanced Cancers Trial - breast, non-small cell lung, colorectal, ovarian, phase 1 (patients) - Full Text View - ClinicalTrials.gov UHN (Toronto)

 Advanced cancer

Advanced breast, non-small cell lung, colorectal and ovarian cancers; as well as patients who are phase I trial candidates

 

Purpose

Substantial progress has been made in the treatment of cancer through the use of targeted therapies, but what works for one patient might not work for another patient. Certain drugs are now being developed that target specific molecules in the body that are believed to be part of the disease.

Biomarkers are specific characteristics of the cancer that may help provide prognostic information (i.e. how well patients will be regardless of the treatments given) or help predict sensitivity or resistance to a specific treatment.

The study will collect archival tumor samples (previously collected biopsy or surgical tumor samples) to provide biomarker data about a patient's cancer, in order to help their physicians to identify which clinical trials of molecularly targeted therapies may be most appropriate for the patient in the future.

Integrated Molecular Profiling in Advanced Cancers Trial (IMPACT)

This study is not yet open for participant recruitment.

Verified on January 2012 by University Health Network, Toronto

First Received on January 4, 2012.   Last Updated on January 5, 2012   History of Changes

Sponsor:	University Health Network, Toronto
Collaborator:	Princess Margaret Hospital, Canada
Information provided by (Responsible Party):	University Health Network, Toronto
ClinicalTrials.gov Identifier:	NCT01505400

Training a New Generation of Breast Surgeons: Are We Succeeding?

Prognostic significance of L1CAM in (serous) ovarian cancer and its role in constitutive NF-κB activation

Conclusions:
L1CAM expression contributes to the invasive and metastatic phenotype of serous ovarian carcinoma. L1CAM expression and shedding in the tumor microenvironment could contribute to enhanced invasion and tumor progression through increased IL-1β production and NF-κB activation.

open access: Development and validation of a prediction index for hand-foot skin reaction in cancer patients receiving sorafenib

Background: This study describes a repeated measures prediction index to identify patients at high risk of ≥ grade 2 hand-foot skin reaction (HFSR) before each week of sorafenib therapy.

Results: Pretreatment white blood cell count, female gender, good performance status, presence of lung and liver metastases and number of affected organs were predictors for ≥ grade 2 HFSR.

U.S. - Planned Cooperative Group Merger Is Generating Concern - NCI clinical trials - gynecologic oncologists, funding, more common cancers, GOG....

A proposed overhaul of the National Cancer Institute’s clinical trials system has created anxiety among gynecologic researchers who fear projects in women’s cancer will be diminished in a scramble for funding with more common malignancies.......

Study of Medicare Patients Finds Most Hospital Errors Unreported - NYTimes.com

WASHINGTON — Hospital employees recognize and report only one out of seven errors, accidents and other events that harm Medicare patients while they are hospitalized, federal investigators say in a new report.

Yet even after hospitals investigate preventable injuries and infections that have been reported, they rarely change their practices to prevent repetition of the “adverse events,” according to the study, from Daniel R. Levinson, inspector general of the Department of Health and Human Services.......

Pathology of Breast and Ovarian Cancers among BRCA1 and BRCA2 Mutation Carriers: Results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA)

Background: Previously, small studies have found that BRCA1 and BRCA2 breast tumors differ in their pathology. Analysis of larger datasets of mutation carriers should allow further tumor characterization. 

Methods: We used data from 4,325 BRCA1 and 2,568 BRCA2 mutation carriers to analyze the pathology of invasive breast, ovarian, and contralateral breast cancers. 

There were no significant differences in ovarian cancer morphology between BRCA1 and BRCA2 carriers (serous: 67%; mucinous: 1%; endometrioid: 12%; clear-cell: 2%). 

Genomics|Update| - Cancer Program Standards 2012 ensuring patient-centered care

Announcements

• Cancer Program Standards 2012: Ensuring Patient-Centered Care [PDF 3.58 MB] from the American College of Surgeons includes new standards for Risk Assessment and Genetic Counseling.

Using Core Public Health Functions to Promote BRCA Best Practices among Health Plans.

pdf file:

http://content.karger.com/produktedb/produkte.asp?doi=10.1159/000334267&typ=pdf

Cochrane Evidence Updates - Antiemetics: American Society of Clinical Oncology clinical practice guideline update

Clinicians underestimate the incidence of nausea, which is not as well controlled as emesis (vomiting).

Cochrane Evidence Updates - Information interventions for orienting patients and their carers to cancer care facilities (including professional commentaries)

AUTHORS' CONCLUSIONS:
This review has demonstrated the feasibility and some potential benefits of orientation interventions. There was a low level of evidence suggesting that orientation interventions can reduce distress in patients. However, most of the other outcomes remain inconclusive (patient knowledge recall/ satisfaction). The majority of studies were subject to high risk of bias, and were likely to be insufficiently powered. Further well conducted and powered RCTs are required to provide evidence for determining the most appropriate intensity, nature, mode and resources for such interventions. Patient and carer-focused outcomes should be included.

open access: BMJ - Identifying women with suspected ovarian cancer in primary care: derivation and validation of algorithm | BMJ

Objective 

To derive and validate an algorithm to estimate the absolute risk of having ovarian cancer in women with and without symptoms.

Main outcome The primary outcome was incident diagnosis of ovarian cancer recorded in the next two years.

The incidence rate in our population was higher than published national data based on cancer registries.2

What is already known on this topic

• Ovarian cancer is the second most common gynaecological cancer and most women are diagnosed with late stage disease, which has a poor survival rate
• Earlier diagnosis could improve with more targeted investigation of symptomatic patients and increased public awareness of symptoms, which is a major challenge given the non-specific nature of some of the symptoms

What this study adds

• An algorithm based on simple clinical variables such as age, family history of ovarian cancer, anaemia, abdominal pain, abdominal distension, rectal bleeding, postmenopausal bleeding, appetite loss, and weight loss, which the patient is likely to know or which are routinely recorded in general practice computer systems, can estimate absolute risk of ovarian cancer in women with and without symptoms in primary care
• The algorithm could be integrated into general practice clinical computer systems and used to assess risk in women presenting with and without symptoms

Vermillion plans to reduce headcount, expenses - financial news (OVA1)

Vermillion Inc. VRML -2.76% plans to reduce its headcount and other expenses and focus on strengthening sales of its ovarian cancer testing product (OVA1)  this year.

Epigenomics Initiates PMA Submission for Colorectal Cancer Test | GenomeWeb Daily News | MDx | GenomeWeb

For its clinical module, Epigenomics will need to demonstrate that Epi proColon performs at least as well as fecal immunochemical testing, it said, adding that it has been in discussions with FDA about the design for its clinical study, which it expects to initiate in the coming months after the study's protocol has been finalized.

The clinical module for the PMA submission will include results of the head-to-head comparison with fecal immunochemical testing, previously announced data from a clinical validation study in a cohort of prospectively collected samples, and other clinical study results.

Last month, the Berlin, Germany-based molecular diagnostics firm announced clinical validation study results for the test. The test demonstrated 68 percent sensitivity and 80 percent specificity.

Medicine's Biggest Threat - Forbes

Medicine’s biggest threat is not a highly resistant microorganism or rising costs or an aging population or workforce shortages. It is something less obvious and more dangerous: the issue of missing data.

Clinical Care Options - Oncology CME - The Right Care for the Younger Patient: Meeting the Needs of Adolescents and Young Adults With Cancer

Learning Objectives

Upon completion of this activity, participants should be able to:

• Describe the physical and psychosocial challenges facing the AYA cancer patient
• Suggest the most suitable treatment strategy for individual AYA patients with cancer based on current evidence
• Apply current evidence to select treatment centers (adult or pediatric) that optimize treatment for AYA patients

Clinical Care Options - Oncology CME - An Update on Metastatic Breast Cancer

Clinical Care Options - Oncology CME - An Update on Early Breast Cancer

British Journal of Cancer - Personalised cancer follow-up: risk stratification, needs assessment or both

BMC Cancer | Systematic review: conservative treatments for secondary lymphedema

Results

Thirty-six English-language and eight non-English-language studies were included in the review. Most of these studies involved upper-limb lymphedema secondary to breast cancer. Despite lymphedema's chronicity, lengths of follow-up in most studies were under six months. Many trial reports contained inadequate descriptions of randomization, blinding, and methods to assess harms. Most observational studies did not control for confounding. Many studies showed that active treatments reduced the size of lymphatic limbs, although extensive between-study heterogeneity in areas such as treatment comparisons and protocols, and outcome measures, prevented us from assessing whether any one treatment was superior. This heterogeneity also precluded us from statistically pooling results. Harms were rare (<1% incidence) and mostly minor (e.g., headache, arm pain).

Conclusions

The literature contains no evidence to suggest the most effective treatment for secondary lymphedema. Harms are few and unlikely to cause major clinical problems.

Ovarian Failure, VTE Risks Added to Avastin Label - in Product Alert, Prescriptions from MedPage Today

ASTRO: Brain Metastases Common in Ovarian Cancer - in Clinical Context, Ovarian Cancer from MedPage Today

BMJ: Discipline Researchers Who Withhold Research Results - in Public Health & Policy, Clinical Trials from MedPage Today

Walking a tightrope: oncologists' perspective on providing information to women with recurrent ovarian cancer (ROC) during the medical encounter.

Anticancer therapies in specialized palliative care—a multicenter survey (HOPE project)

In conclusion, this study shows that the use of ACT refers to a distinguishable subgroup of palliative care patients in distinct institutions and is therefore more than a mere expansion of the therapeutic (pharmacologic) spectrum in palliative care. The continuing debate about integrating ACT into palliative care concepts and about early integration of palliative care into oncology has now gained new arguments.

Jan 2012: Race, insurance influence treatment of advanced ovarian cancer

Table 1 (includes history of breast and/or ovarian cancers but not other cancers (eg. colorectal/Lynch Syndrome)

Effect of Screening on Ovarian Cancer Mortality, June 8, 2011 — JAMA

louisgray.com: Social Networking With Strangers

Successful treatment of adult-type granulosa cell tumor of the ovary by palliative radiotherapy - Journal of Obstetrics and Gynaecology Research - Wiley Online Library

She is still alive with no signs of tumor progression for 30 months.

JMIR-Can Tweets Predict Citations? Metrics of Social Impact Based on Twitter and Correlation with Traditional Metrics of Scientific Impact | Eysenbach | Journal of Medical Internet Research

Conclusions: Tweets can predict highly cited articles within the first 3 days of article publication.....

Metastatic Tumors to the Urinary Bladder: Clinicopathologic

Abstract

Secondary neoplasms of the urinary bladder are uncommon, with metastatic tumors being an even rarer event. The authors studied the clinicopathology of 11 cases of metastatic tumors to bladder, which were collected from their archives between 1995 and 2010. The most common metastases in this series were breast. Some unusual metastases, including several not being previously reported, were also presented, namely, ileal carcinoid tumor, ileal gastrointestinal stromal tumor, ovarian squamous carcinoma, pancreatic gastrinoma, and renal collecting duct carcinoma. Vast majority of these patients (10/11, 91%) were female. Ninety percent of the patients presented with hematuria and/or obstructive urinary symptom as well as bladder lesions in the area of trigone, posterior wall, and/or bladder neck. Seven of the 11 patients had a known history of other metastases besides the bladder. Most of the patients (4/7, 57%) died within 1 year after diagnosis of bladder metastasis. Metastasis must be distinguished from a primary bladder neoplasm. Morphology and clinical correlation supplemented with immunohistochemical study is critical for the correct diagnosis.

Narod: Should All Women With Breast Cancer Be Tested for BRCA Mutations at the Time of Diagnosis?

....For now, perhaps the simplest recommendation is to test women under age 50 years with triple-negative breast cancer and women with a family history of early-onset breast cancer or ovarian cancer......

BMJ Jan 3, 2012 - selected articles: evidence; randomized clinical trials; publication bias; meta-analyses; Medline....

Effect of reporting bias on meta-analyses of drug trials: reanalysis of meta-analyses
 

Published 3 Jan 2012

Publication of NIH funded trials registered in ClinicalTrials.gov: cross sectional analysis

Published 3 Jan 2012

Compliance with mandatory reporting of clinical trial results on ClinicalTrials.gov: cross sectional study

Published 3 Jan 2012

Understanding why evidence from randomised clinical trials may not be retrieved from Medline: comparison of indexed and non-indexed records

Published 3 Jan 2012

Assessment of publication bias, selection bias, and unavailable data in meta-analyses using individual participant data

Published 3 Jan 2012

Missing Data: The Elephant That's Not in the Room (Guest Post) - Forbes

Restless Legs Syndrome - eMedicineHealth: Treatment, Symptoms, Causes

Inviting Patients to Read Their Doctors' Notes: Patients and Doctors Look Ahead

abstract plus downloadable full free access (pdf):
Inviting Patients to Read Their Doctors' Notes: Patients and Doctors Look Ahead

also (note disparities in opinions):
Figures 1; Figures 2

Pelvic Mass Associated With Raised CA 125 For Benign Condition: A Case Report

Background:
Elevated levels of CA 125 with clinical evidence of significant weight loss and associated pelvic mass is highly suggestive of ovarian malignancy, this creates a diagnostic dilemma with the knowledge that several benign pelvic conditions may present with same findings.
Conclusion:
The presence of a pelvic mass with a raised CA 125 of 1450 units/ml, lymphadenopathy and other associated suspicious features on CT scan suggested an ovarian malignancy. A subsequent fall of CA 125 to 23 units/ml pointed to an inflammatory condition as was found intraoperatively. Raised CA 125 levels can be misleading, as illustrated in this case, a differential diagnosis of inflammatory pelvic condition should always be considered in young patients. While CT and CA 125 aids in diagnosis they should not completely supplant the need to rely on clinical history and examination findings.

Medical Daily: Ovarian Cancer Vaccines Can be Made More Quickly

NIH launches first online genetics course for social and behavioral scientists, January 3, 2012 News Release - National Institutes of Health (NIH)

NIH launches first online genetics course for social and behavioral scientists

A new genetics educational program will provide social and behavioral scientists with sufficient genetics background to allow them to engage effectively in interdisciplinary research with genetics researchers. The Office of Behavioral and Social Sciences Research (OBSSR) at the National Institutes of Health, partnered with the National Coalition for Health Professional Education in Genetics to create the free, Web-based project...........

Genetics education and resources for social scientists

Genetics vs. Genomics

In popular media and common speech, the words "genetic" and "genomic" are often used interchangeably. However, to a geneticist, these terms have specific meanings. To appreciate the difference, we must first understand something about the structure of genetic material.
Genetic information is stored in the molecule DNA, which consists of a string of chemicals called bases. The order of bases on the string, called the "sequence", determines the meaning of the genetic message. A gene is a specific stretch of bases that provides instructions for making a particular product, such as a piece of a hormone or enzyme. Humans have many thousands of genes, spaced across the entire set of DNA, which is packaged into 23 pairs of chromosomes. However, there are many DNA sequences in-between genes that do not directly encode specific products. Some of these sequences modify the way that genes are expressed. Other sequences do not have a known function.

Read the full story

Ex-Medicare Chief (Don) Berwick Takes Gloves Off - Washington Wire - WSJ

Potentiation of a p53-SLP vaccine by cyclophosphamide in ovarian cancer, a single arm phase II study.

Abstract

The purpose of the current phase II single-arm clinical trial was to evaluate whether pre-treatment with low-dose cyclophosphamide improves immunogenicity of a p53-synthetic long peptide (SLP) vaccine in patients with recurrent ovarian cancer. Ovarian cancer patients with elevated serum levels of CA-125 after primary treatment were immunized four times with the p53-SLP vaccine.........The outcome of this phase II trial warrants new studies on the use of low-dose cyclophosphamide to potentiate the immunogenicity of the p53-SLP vaccine, or other anti-tumor vaccines.

Attitudes of Patients With Gynecological and Breast Cancer Toward Integration of Complementary Medicine in Cancer Care

Conclusion:
Although patients with gynecological malignancies use CAM significantly more than patients with breast cancer, both groups share similar conceptions regarding the active role of their gynecologist oncologists in the process of CAM integration within supportive care and expect CAM consultation to focus on improving their well-being.

Impact of Chemotherapy-Induced Nausea and Vomiting on Quality of Life in Indonesian Patients With Gynecologic Cancer

Conclusions:
Patients reported a negative impact on the QoL of delayed emesis after chemotherapy. Poor prophylaxis of patients’ nausea and vomiting after chemotherapy interferes with patients’ QoL. Medical and behavioral interventions may help to alleviate the negative consequences of chemotherapeutic treatment in patients with gynecologic cancers treated with suboptimal antiemetics.

Intravenous/Intraperitoneal Paclitaxel and Intraperitoneal C... : International Journal of Gynecological Cancer

Objective:
This study aimed to evaluate intravenous (IV)/intraperitoneal (IP) paclitaxel and IP carboplatin (TCipTip therapy) feasibility in epithelial ovarian (EOC), fallopian tube (FTC), or peritoneal carcinoma (PC) patients.


Methods:
From December 2007 to August 2010, 20 women with histologically confirmed stage IC to IV EOC, FTC, or PC.....

Identifying Clinical Improvement in Consolidation Single-Arm Phase 2 Trials in Patients With Ovarian Cancer in Second or Greater Clinical Remission

Abstract

Objective: Estimates of progression-free survival (PFS) from single-arm phase 2 consolidation/maintenance trials for recurrent ovarian cancer are usually interpreted in the context of historical controls. We illustrate how the duration of second-line therapy (SLT), the time on the investigational therapy (IT), and patient enrollment plan can affect efficacy measures from maintenance trials and might result in underpowered studies.

Conclusions:

Designs of nonrandomized consolidation trials that aim to prolong PFS must consider the effect of the duration of SLT on the end point definition and on required sample size. If IT is given concurrently with SLT, and after SLT, then SLT duration must be restricted per protocol eligibility, so that a comparison with historical data from other single-arm phase 2 studies is unbiased. If IT is given after SLT, the duration of SLT should be taken into account in the design stage because it will affect statistical power and sample size.

Phase II Study of Docetaxel Weekly in Combination With Carboplatin Every 3 Weeks as First-Line Chemotherapy in Stage IIB to Stage IV Epithelial Ovarian Cancer

 Objectives: 
The purpose of this study was to assess the response rate, toxicity, progression-free survival, and overall survival in a series of patients with advanced-stage ovarian carcinoma treated with a first-line weekly docetaxel and 3 weekly carboplatin regimen.
 
Conclusions:
The tolerable hematologic toxicity (no need for colony-stimulating factors) and the low rate of neurotoxicity (only grades 1–2) and response rates in line with the standard 3-week paclitaxel-carboplatin regimen for advanced primary ovarian carcinoma after suboptimal cytoreductive surgery make this regimen an interesting alternative in selected patients.

published Oct 2011 - full free access: The Role of Hormonal Therapy in Gynecological Cancers-Curren... : International Journal of Gynecological Cancer

Abstract (and full free access to full paper)

Many gynecological cancers, including epithelial and stromal ovarian cancers; endometrial carcinomas; and some gynecological sarcomas, in particular endometrial stromal sarcomas, express estrogen and/ or progesterone receptors. Hormonal therapy, typically progestogens or tamoxifen, is commonly prescribed to patients with potentially hormone-sensitive recurrent or metastatic gynecological cancers with very variable response rates and clinical benefit reported. Aromatase inhibitors are now widely used to treat postmenopausal women with hormone receptor-positive breast cancers as they have greater activity than tamoxifen and are generally better tolerated. The role of aromatase inhibitors in gynecological cancers is uncertain and has not been well studied, although they do appear to be active. The current evidence to support the use of hormonal therapies including aromatase inhibitors in gynecological cancers is reviewed, and the gaps in our knowledge highlighted.

Loss of ARID1A-Associated Protein Expression is a Frequent Event in Clear Cell and Endometrioid Ovarian Cancers

Abstract

Background: Inactivating somatic mutations in the ARID1A gene are described in a significant fraction of clear cell and endometrioid ovarian cancers leading to loss of the corresponding protein (BAF250a).

Conclusions:

These data confirm that loss of the ARID1A-encoded protein BAF250a is a frequent event in the genesis of clear cell and endometrioid ovarian cancers. Loss of BAF250a was not associated with clinical or epidemiologic characteristics. One explanation for these findings is that inactivation of the chromatin remodeling pathway may be a requisite event in the development of these cancers.

Journal of Clinical Epidemiology : Using short information leaflets as recruitment tools did not improve recruitment: a randomized controlled trial

Objective

To assess if the type of patient information leaflet (PIL) received at an initial invitation to participate in a randomized trial influences the number of patients recruited.

Conclusion

Providing patients with shorter PILs when inviting them to participate in research does not affect the numbers who are subsequently recruited and yields more ineligible patients. Therefore, it is recommended to use the full PIL as a recruitment tool.

Can Canada get on with national pharmacare already? (the politics of cancer/healthcare)

We believe the public’s choice would be health care. With Canadians suffering and, indeed, dying every day from inadequate drug coverage, and with a national pharmaceutical strategy already in place, the lack of action on pharmacare is inexcusable.

BMC Medicine | Abstract/free full text: Septin 9 methylated DNA is a sensitive and specific blood test for colorectal cancer (small study)

The complete article is available as a provisional PDF.

Background
About half of Americans 50 to 75 years old do not follow recommended colorectal cancer (CRC) screening guidelines, leaving 40 million individuals unscreened. A simple blood test would increase
screening compliance, promoting early detection and better patient outcomes. The objective of this study is to demonstrate the performance of an improved sensitivity blood-based Septin 9 (SEPT9) methylated
DNA test for colorectal cancer. Study variables include clinical stage, tumor location and histologic grade.

What Is Distracting Doctors More Than Electronic Devices? - Better Health (in response to NYT article)

Survey Asks Doctors And Patients If Doctor’s Notes Should Be In The EHR (electronic health records)

Survey Reveals Just How Stressed Physicians Really Are - Better Health

in research: Combinations of Resveratrol, Cisplatin and Oxaliplatin Applied to Human Ovarian Cancer Cells

Follow-up with CA125 after primary therapy of advanced ovarian cancer has major implications for treatment outcome and trial performances and should not be routinely performed

Follow-up with CA125 after primary therapy of advanced ovarian cancer: in favor of continuing to prescribe CA125 during follow-up

Quality control in ovarian cancer surgery

If the profession does not institute adequate internal regulation of the quality of ovarian cancer surgery, regulation is likely to be imposed by government.

Correction: ABCB1 (MDR1) Polymorphisms and Progression-Free Survival among Women with Ovarian Cancer following Paclitaxel/Carboplatin Chemotherapy

link to original article:

The authors of this article (Clin Cancer Res 2008;14:5594-601), which was published in the September 1, 2008, issue of Clinical Cancer Research (1), wish to inform the scientific community that the results of the analysis of the ABCB1 3435C>T and 1236C>T SNPs presented were incorrectly reported due to a corrupted analysis file.

Completion of Adjuvant Chemotherapy and Use of Health Services for Older Women (65 yrs+) With Epithelial Ovarian Cancer (SEER data/Medicare)

Results
Among 4,617 patients with untreated ovarian cancer, 1,329 (28.8%) received no chemotherapy, 1,139 (24.7%) received a partial course of chemotherapy, and 2,149 (46.5%) completed chemotherapy.

Conclusion
There is considerable room for improvement in helping older patients with ovarian cancer initiate and complete chemotherapy. The oldest women who completed chemotherapy in this study did not use health services more than younger women did.

Skin Tumors Induced by Sorafenib; Paradoxic RAS–RAF Pathway Activation and Oncogenic Mutations of HRAS, TP53, and TGFBR1

Conclusion:

Sorafenib induces keratinocyte proliferation in vivo and a time- and dose-dependent activation of the MAP kinase pathway in vitro. It is associated with a spectrum of lesions ranging from benign follicular cystic lesions to KA-like SCC. Additional and potentially preexisting somatic genetic events, like UV-induced mutations, might influence the evolution of benign lesions to more proliferative and malignant tumors.

Ovarian cancer drug fail (and that’s the good news?) author/ovarian cancer survivor: Donna Trussell - She the People: - The Washington Post

Getting Doctors And Patients On The Same Team: A Basketball Metaphor For Health Care - Better Health

....But for the business of medicine, it’s all about the zone.... But what happens when the patients change tactics?.....What if the patient’s psyche or medical issues don’t follow the typical playbook?....So the players become confused.....

Loss of ARID1A protein expression occurs as an early event in ovarian clear-cell carcinoma development and frequently coexists with PIK3CA mutations : Modern Pathology

ARID1A is a recently identified tumor suppressor gene that is mutated in ~50% of ovarian clear-cell carcinomas. This mutation is associated with loss of ARID1A protein expression as assessed by immunohistochemistry. The present study aimed at determining the timing of the loss of ARID1A protein expression during the development of ovarian clear-cell carcinoma and assessing its relevance in correlation to PIK3CA gene mutations......

A Prospective Study of Serum 25-Hydroxyvitamin D (vitamin D) Levels, Blood Pressure, and Incident Hypertension in Postmenopausal Women

 authors.....for the Women’s Health Initiative Investigators

In postmenopausal women in this study, serum levels of 25(OH)D were not related to changes in blood pressure, and evidence for an association with lower risk of incident hypertension was weak.

Women of Teal: 4 Years of Blogging -

Thanks to the statistics the Blogger software started keeping in May 2009, I know that my blog has reached far from the Garden State. I have also been read in Germany, Great Britain, Russia, Canada, South Korea, France , the Netherlands, Iran and Australia and I have between 1,500 and 2,200 page views a month.....

Serum HE4 levels are less frequently elevated than CA125 in women with benign gynecologic disorders

Introduction

HE4 is a novel biomarker for ovarian cancer. This study measured HE4 and CA125 levels in women with benign gynecologic disorders.

Serum Levels of the Ovarian Cancer Biomarker HE4 are decreased in Pregnancy and Increase with Age

Objectives:

To establish normal ranges for HE4 serum levels in healthy women.

2013 results to show if bevacizumab (Avastin) prolongs life in ovarian cancer - - media

NEW YORK (Reuters Health) - The coauthor of a study that helped convince the European Commission on Friday to approve bevacizumab (Avastin) as an initial post-surgical treatment for advanced ovarian cancer predicted that some doctors may be reluctant to use the drug until mortality data become available in 2013.......

Amazon.com: Methods of Cancer Diagnosis, Therapy, and Prognosis: Ovarian Cancer..... (published 2010)

Blogger's Note: available on kindle; new, used

Book Description

ISBN-10: 9048129176 | ISBN-13: 978-9048129171 | Publication Date: February 18, 2010 | Edition: 1st Edition

This sixth volume in the series Methods of Cancer Diagnosis, Therapy, and Prognosis discusses Ovarian Cancer, Renal Cancer, Urogenitary Cancer, Urinary Bladder Cancer, Cervical Uterine Cancer, Skin Cancer, Leukemia, Multiple Myeloma and Sarcoma. Both standard and emerging therapies for these cancers, written by expert oncologists/pathologists in this field, are included.

This fully illustrated volume

• Identifies biomarkers based on genetic alterations for clear cell ovarian adenocarcinoma.
• Identifies subgroups of ovarian cancer by using differential gene expression.
• Includes the application of the power-Doppler imaging for distinguishing benign from malignant complex adrenal masses in ovarian cancer.
• Emphasizes the advantage of using cytoreduction surgery for diagnosing advanced ovarian cancer.
• and other cancers/ topics

The technological advances presented in this volume are expected to expedite new discoveries and their translation to clinical practice. The field of oncology will benefit the most from these advanced methods, as a combination of therapies and personalized medicine will improve early detection of these different types of cancer.

Professor Hayat has summarized the problems associated with the complexities of research publications and has been successful in editing a must-read volume for oncologists, cancer researchers,

Follow-up with CA125 after primary therapy of adva... [Ann Oncol. 2011] - PubMed - NCBI

CONCLUSIONS:

Women should be advised not to have routine CA125 measurements, providing they are well and have no symptoms suggesting relapse. In asymptomatic patients with a rising CA125 level, chemotherapy can be delayed. Earlier stopping of maintenance therapy just because of rising CA125 might deny patients continuing benefit from that therapy. Use of CA125 to define progression could result in platinum-sensitive patients being falsely classified as platinum resistant.

Table of Contents — Dec 2011 - 8th International Symposium on Advanced Ovarian Cancer: Optimal Therapy 4 Mar 2011, Valencia Spain

Blogger's Note: abstracts - subscription req'd ($$$) to access full view symposium articles

1. R. C. Bast, Jr Molecular approaches to personalizing management of ovarian cancer Ann Oncol (2011) 22(Suppl 8): viii5-viii15 doi:10.1093/annonc/mdr516 
2. N. Urban Designing early detection programs for ovarian cancer Ann Oncol (2011) 22(Suppl 8): viii6-viii18 doi:10.1093/annonc/mdr472 
3. N. F. Hacker Quality control in ovarian cancer surgery Ann Oncol (2011) 22(Suppl 8): viii19-viii22 doi:10.1093/annonc/mdr517 S. 
4. Kang and S.-Y. Park To predict or not to predict? The dilemma of predicting the risk of suboptimal cytoreduction in ovarian cancer Ann Oncol (2011) 22(Suppl 8): viii23-viii28 doi:10.1093/annonc/mdr530 
5. N. Katsumata Dose-dense therapy is of benefit in primary treatment of ovarian cancer? In favor Ann Oncol (2011) 22(Suppl 8): viii29-viii32 doi:10.1093/annonc/mdr468 
6. M. E. L. van der Burg, I. A. Boere, and P. M. J. J. Berns Dose-dense therapy is of benefit in primary treatment of ovarian cancer: contra Ann Oncol (2011) 22(Suppl 8): viii33-viii39 doi:10.1093/annonc/mdr514 
7. S. Pignata, L. Cannella, D. Leopardo, G. S. Bruni, G. Facchini, and C. Pisano Follow-up with CA125 after primary therapy of advanced ovarian cancer: in favor of continuing to prescribe CA125 during follow-up Ann Oncol (2011) 22(Suppl 8): viii40-viii44 doi:10.1093/annonc/mdr470 
8. G. J. S. Rustin Follow-up with CA125 after primary therapy of advanced ovarian cancer has major implications for treatment outcome and trial performances and should not be routinely performed Ann Oncol (2011) 22(Suppl 8): viii45-viii48 doi:10.1093/annonc/mdr471 
9. E. A. Eisenhauer Optimal assessment of response in ovarian cancer Ann Oncol (2011) 22(Suppl 8): viii49-viii51 doi:10.1093/annonc/mdr467 
10. Michael A. Bookman Update of randomized trials in first-line treatment Ann Oncol (2011) 22(Suppl 8): Viii52-viii60 doi:10.1093/annonc/mdr466 
11. E. Pujade-Lauraine and J. Alexandre Update of randomized trials in recurrent disease Ann Oncol (2011) 22(Suppl 8): viii61-viii64 doi:10.1093/annonc/mdr518 
12. R. A. Burger Antiangiogenic agents should be integrated into the standard treatment for patients with ovarian cancer Ann Oncol (2011) 22(Suppl 8): viii65-viii68 doi:10.1093/annonc/mdr529 
13. M. Markman The use of bevacizumab in the management of ovarian cancer: an argument for single-agent rather than combination therapy Ann Oncol (2011) 22(Suppl 8): viii69-viii71 doi:10.1093/annonc/mdr469 
14. C. Sessa Update on PARP1 inhibitors in ovarian cancer Ann Oncol (2011) 22(Suppl 8): viii72-viii76 doi:10.1093/annonc/mdr528 K. 
15. Bell-McGuinn, J. Konner, W. Tew, and D. R. Spriggs New drugs for ovarian cancer Ann Oncol (2011) 22(Suppl 8): viii77-viii82 doi:10.1093/annonc/mdr531

Gynecologic Oncology : Withdrawal from familial ovarian cancer screening for surgery: Findings from a psychological evaluation study (PsyFOCS)

Highlights

► Previous negative experiences of OC screening might lead women to opt for surgery.
► OC screening may be an interim risk management strategy before opting for surgery.

Gynecologic Oncology : The association between endometriosis and ovarian cancer: A review of histological, genetic and molecular alterations

.... PTEN play a part in the malignant transformation of endometriosis, some studies have revealed TP53 mutations in endometriotic lesions, and mutation of ARID1A (clear cell)

Highlights
► Atypical endometriosis is a transition from benign endometriosis to carcinoma.
► Endometriosis is characterized by genetic instability.
► Oxidative stress, inflammation and hyperestrogenism link endometriosis with cancer.

Gynecologic Oncology : There is no decision to make: Experiences and attitudes toward treatment-focused genetic testing among women diagnosed with ovarian cancer

Highlights

► Women's views regarding genetic testing at diagnosis of ovarian cancer 
► This ‘treatment-focused’ genetic testing is highly acceptable 
► Advantages of genetic testing at diagnosis outweigh the disadvantages

Androgen receptor expression is a biological marker for androgen sensitivity in high grade serous epithelial ovarian cancer

Highlights

► Androgen receptor expression correlates with androgen sensitivity in ovarian cancer.
► Androgen receptor expression decreases with chemotherapy.
► Androgen receptor expression is a biomarker for androgen therapy in ovarian cancer.

Second Malignancies Among Elderly Survivors of Cancer

 Blogger's note: selected text referencing ovarian cancer:

 Ovarian Cancer Survivors

Most ovarian cancer patients present with relatively late stage disease, and thus the overall 5-year survival rate is only 46% [1]. However, in women who survive ≥5 years following ovarian cancer, the risk for developing a second malignancy is high, with a 31% higher risk than in the general population [54]. The cancers most often seen after ovarian cancer are breast, colorectal, and bladder cancer and leukemia [55]. Breast and colon cancer are most often seen after ovarian cancer in younger women, largely because of the prevalence of genetic syndromes, such as BRCA mutation and hereditary nonpolyposis colorectal cancer  (Lynch Syndrome),  that predispose to these tumors and ovarian cancer [27, 29, 55]. Some rare tumors have also been associated with ovarian cancer, including biliary tract cancer and both the ocular and skin variants of malignant melanoma, and are also thought to be a result of genetic syndromes such as BRCA-2 mutation [26, 54, 56].

However, an excess risk for second malignancies has been seen in women diagnosed with primary cancer of the ovary at age 50–69 years as well, and these second cancers appear more likely to be a result of treatment. In particular, the risks for bladder, soft tissue, and bone cancers are substantially higher in women who received radiation, and these risks become most apparent ≥10 years following the initial radiation therapy [54, 57].

The risk with chemotherapy in the development of second cancers is also apparent across all age groups. The risk for the subsequent development of both AML and acute lymphocytic leukemia have been shown to be significantly higher in women following a primary diagnosis of ovarian cancer, even in women aged ≥70 years at the time of their primary diagnosis and in women who did not receive radiation [54]. Historically, this greater risk was attributed to alkylating chemotherapeutic agents, such as melphalan and chlorambucil [32], but these agents have largely fallen out of use in the treatment of ovarian cancer. More recently, platinum-based chemotherapy, which is routinely used in ovarian cancer treatment, has also been associated with a higher late risk for leukemia. This was demonstrated in a large registry case–control study of women who developed leukemia after ovarian cancer. Of note, 71% of patients who developed leukemia were aged ≥60 years at the time of their ovarian cancer diagnosis, whereas 29% were aged ≥70 years [31]......

......Further evidence-based guidelines are needed for early detection and treatment of second malignancies in older adults, and physicians caring for this population should integrate age, health status, projected life expectancy, and patient preferences when deciding upon screening and prevention measures.  

Revisiting the Role of Antiandrogen Strategies in Ovarian Cancer

link to abstract

selected excerpts (in efforts to understand the issues):

Epidemiological Data on Androgens and the Risk for EOC

In women, androgens are mainly synthesized in the adrenal glands, the ovaries, and adipose tissue, and they have an important physiological significance for bone and muscle growth and maintenance as well as cognitive function [1, 5]. There is a growing body of evidence supporting the notion that androgens influence proliferation of the normal ovarian epithelium and are a risk factor for EOC......

First, most clinical trials evaluating the use of androgen blockade for the treatment of EOC have been small, nonrandomized studies involving patients with platinum-resistant disease......
 
Third, most clinical trials assessing anti-AR strategies in EOC have not measured AR expression. The trials that did measure it used IHC, the results of which may not always reflect AR activity in EOC.

Factors Associated with Altered Long-Term Well-Being After Prophylactic Salpingo-Oophorectomy Among Women at Increased Hereditary Risk for Breast and Ovarian Cancer

Blogger's note: full view may require $$$ (subscription)

link to abstract

Year in Review: Gene Patent Case May Head to Supreme Court - Myriad + Mayo/Prometheus Labs