SAN FRANCISCO -- Oral contraceptives and medroxyprogesterone acetate
(MPA, DepoProvera) may have potential as
chemopreventive agents for
endometrial cancer in women with Lynch syndrome, biomarker data from a
small randomized trial suggest.
"Despite the favorable results, Lu noted that the trial required six
years to complete, as investigators in the multicenter study had to
screen 708 patients to identify 51 who met entry criteria and agreed to
participate, including undergoing two endometrial biopsies three months
apart."
read the full article & then my comments as below:
Without the benefit of the full paper, I found this article, in part to be quite confusing. In particular "screened women with diagnosed Lynch syndrome". While the first paragraph of the article reflects the focus on endometrial cancer in women with Lynch Syndrome, the paragraph as below, could also be interpreted to include ovarian cancer as well. So, were ovarian cancer patients with Lynch Syndrome included in this study? Chemoprevention in the form of oral contraceptives in the general ovarian cancer populations is well understood, whether or not this applies to ovarian cancer women with Lynch Syndrome may be yet to be determined.
Clarification, please?
Sandi Pniauskas
"To examine the chemopreventive effects of oral contraceptives and DepoProvera in women with Lynch syndrome, investigators conducted a randomized phase II clinical trial. They screened women with diagnosed Lynch syndrome and evaluated them with transvaginal ultrasound and endometrial biopsy."
No comments:
Post a Comment
Your comments?
Note: Only a member of this blog may post a comment.