Conclusions: EpCAM is highly expressed in primary chemotherapy- resistant ovarian carcinoma cell lines, and these chemotherapy-resistant tumors are highly sensitive to MT201-mediated cytotoxicity in vitro. MT201 may represent a novel, potentially highly effective treatment option for patients harboring chemotherapy-resistant ovarian carcinoma.

Note: EpCAM epithelial cell adhesion molecule (EpCAM); EpCAM gene can be tested either independently or as part of genetic testing - depending on the testing procedure (eg. Lynch Syndrome); study included clear cell ovarian cancer