Identifying Adverse Drug Reactions Associated with Drug-Drug Interactions: patient/drug safety

Conclusions: This study validates that spontaneous reporting, despite its limitations, can be an important resource for detecting ADRs associated with the concomitant use of interacting drugs. Moreover, our data confirm that DDIs could be a real problem in clinical practice, showing that more than one in five patients exposed to a potential DDI (drug-drug-interaction) experienced a related ADR (adverse drug reaction).