Conclusion:
The present data show that CUP is not a
disease of random metastatic cancers but, instead, a disease of a
defined set of
cancers. The association of CUP with families of
kidney, lung, and colorectal cancers suggests a marked genetic basis
and
shared metastatic mechanisms by many cancer
types. Familial sites shared by CUP generally match those arising in
tissue-of-origin
determinations and, hence, suggest sites of
origin for CUP. Mechanistic exploration of CUP may provide insight into
defense
against primary tumors and the metastatic
process.
An ovarian cancer blog which includes quality resource materials: education, research, social networking, genetics and (some) healthcare politics.
“Not everything that can be counted counts and not everything that counts can be counted.”
Albert Einstein
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