Evaluation of predictive models for the identification in daily practice of patients with lynch syndrome - Intl Jnl of Cancer

"....Both approaches failed to identify two of the eight mutation carriers (the same two patients, aged 67 and 81 years, both with no family history). Thus, like the revised Bethesda guidelines, predictive models did not identify all Lynch syndrome patients in our series of unselected CRC. Our results support systematic screening for MMR deficiency in all new CRC cases."