Use of metformin and the risk of ovarian cancer: A case-control analysis

OBJECTIVE:

To explore the association between use of metformin or other antidiabetic drugs and the risk of ovarian cancer.

CONCLUSION:

In this large epidemiological study long-term use of metformin, but not of sulfonylureas, was associated with a tendency towards a decreased risk of ovarian cancer. Long-term use of insulin was associated with an increased risk of ovarian cancer.