abstract: Distinct Subpopulations of Epithelial Ovarian Cancer Cells Can Differentially Induce Macrophages and T Regulatory Cells Toward a Pro-Tumor Phenotyp

Problem  Presence of immune infiltrates in the tumor does not always correlate with an anti-tumoral immune response. (eg. vaccine therapies...)
Conclusion  We demonstrate that each ovarian cancer cell subpopulation can induce a unique phenotype of macrophages and T cells, both associated with tumor-supportive function.