Blogger's Note: the abstract does not detail MSI-L/MSI-H (colon cancer in Lynch Syndrome)
Experimental Design:
Microsatellite status was assessed
on archival tumor material from patients with stage II and III colon
cancer. Microsatellite
status was next associated with clinical outcome in
control and ASI treatment groups using Kaplan–Meier analysis.
Conclusion:
This retrospective study indicated that
patients with MSI tumors did well, irrespective of treatment arm and
tumor stage.
The data also indicate that the clinical benefit,
measured as recurrence-free survival, from adjuvant ASI treatment of
patients
with colon cancer was restricted to patients with
MSS Dukes B tumors.
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