Funding Oncology Clinical Trials: Are Cooperative Group Trials Sustainable?
Conclusion
The negative trough in the lifetime net
income of a cooperative group trial occurs because follow-up costs are
typically
not funded or are underfunded. CTDs accrue more
patients in new trials to offset that deficit. The CTD uses revenue from
accrual
to existing trials to cross-subsidize past
trials in follow-up. As the number of patients on follow-up increases,
the fiscal
deficit grows larger each year, perpetuating the
cycle.
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