New breast cancer susceptibility gene
"....XRCC2 may also provide a new target for chemotherapy. "A type of drug
called a PARP inhibitor appears to kill tumor cells that have gene
mutations in a particular DNA repair pathway. XRCC2 is in this pathway,
as are BRCA1 and BRCA2. It's reasonably likely that a breast cancer
patient who has a mutation in XRCC2 will respond well to treatment with
PARP inhibitors," said Tavtigian......."
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