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Platinum Resistance is in the Eye of the Beholder « Dr. Robert A. Nagourney – Rational Therapeutics – Blog
"I was recently apprised of an online conversation surrounding the
treatment of platinum refractory and platinum resistant ovarian cancer.
To clarify our terminology, platinum refractory disease refers to cancer
that progresses during platinum therapy. This would be considered the
most platinum resistant of the ovarian patients. The term “platinum
resistant” developed over the last two decades, by Markman and others,
is used to describe patients who initially respond to platinum-based
chemotherapy and then relapse within six months of treatment.
While platinum refractory seems intuitively obvious, it has been
suggested that platinum resistance is somewhat more arbitrary........
included comment from
Liz Mane says:
"Dr. N.
I am the one who opined on a chat room that most oncologists won’t
redeploy carbo to platinum refractory patients right after unsuccessful
front line platinum therapy. However, whoever alerted this comment to
you omitted a crucial qualifying aspect of my argument.
...........(I have a Ph.D. in research science though not
in bio medical field). My conclusion was,.......
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