ScienceDirect.com - Gynecologic Oncology - A randomized parallel-group dietary study for stages II–IV ovarian cancer survivors
A randomized parallel-group dietary study for stages II–IV ovarian cancer survivors
- Received 29 September 2011. Accepted 15 November 2011. Available online 23 November 2011.
Abstract
Objective
Few
studies have examined the dietary habits of ovarian cancer survivors.
Therefore, we conducted a study to assess the feasibility and impact of
two dietary interventions for ovarian cancer survivors.
Methods
In
this randomized, parallel-group study, 51 women (mean age, 53 years)
diagnosed with stages II–IV ovarian cancer were recruited and randomly
assigned to a low fat, high fiber (LFHF) diet or a modified National
Cancer Institute diet supplemented with a soy-based beverage and
encapsulated fruit and vegetable juice concentrates (FVJCs). Changes in
clinical measures, serum carotenoid and tocopherol levels, dietary
intake, anthropometry, and health-related quality of life (HRQOL) were
assessed with paired t-tests.
Results
The
recruitment rate was 25%, and the retention rate was 75% at 6 months.
At baseline, 28% and 45% of women met guidelines for intake of fiber and
of fruits and vegetables, respectively. After 6 months, total serum
carotenoid levels and α- and β-carotene concentrations were
significantly increased in both groups (P < 0.01); however,
β-carotene concentrations were increased more in the FVJC group. Serum
β-cryptoxanthin levels, fiber intake (+ 5.2 g/day), and daily servings
of juice (+ 0.9 servings/day) and vegetables (+ 1.3 servings/day) were
all significantly increased in the LFHF group (all P < 0.05).
Serum levels of albumin, lutein and zeaxanthin, retinol, and retinyl
palmitate were significantly increased in the FVJC group (all P < 0.05). No changes in cancer antigen-125, anthropometry, or HRQOL were observed.
Conclusion
Overall,
this study supports the feasibility of designing dietary interventions
for stages II–IV ovarian cancer survivors and provides preliminary
evidence that a low fat high fiber diet and a diet supplemented with
encapsulated FVJC may increase phytonutrients in ovarian cancer
survivors.
Highlights
►
Many ovarian cancer survivors fail to meet current guidelines for
dietary intake.
► A low-fat diet supplemented with encapsulated fruit and vegetable juice concentrates can improve carotenoid levels.
► Encapsulated fruit and vegetable juice concentrates may help bridge the gap between what is consumed and what is needed.
► A low-fat diet supplemented with encapsulated fruit and vegetable juice concentrates can improve carotenoid levels.
► Encapsulated fruit and vegetable juice concentrates may help bridge the gap between what is consumed and what is needed.
No comments:
Post a Comment
Your comments?
Note: Only a member of this blog may post a comment.