Drug ((naloxegol) Eases Constipation from Opioids

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Action Points

• Note that this study was published as an abstract and presented at a conference. These data and conclusions should be considered preliminary until published in a peer-reviewed journal.
• A peripherally acting opioid receptor antagonist (naloxegol) alleviated opioid-induced constipation in two pivotal phase III trials.
• Note that there were no significant changes in pain scores or daily opioid doses from baseline through 12 weeks, suggesting that the treatment didn't interfere with central opioid analgesia or lead to withdrawal.