Abstract
OBJECTIVES:
Previous
studies have suggested an association between endometriosis and
development of ovarian cancer. A study was performed to evaluate the
cases of ovarian carcinoma associated with endometriosis.
STUDY DESIGN:
The
study includes patients with ovarian carcinoma associated with
endometriosis diagnosed between 2000 and 2010 at Hacettepe University
Hospital, Ankara,
Turkey. A total of
1086 patients who underwent
surgical staging for ovarian carcinoma were analyzed retrospectively for
the presence of histologically documented endometriosis. The clinical
and pathological characteristics of
45 ovarian carcinoma patients
associated with endometriosis were evaluated including histologic
subtype, stage and grade.
RESULTS:
Ovarian carcinoma was
found to be associated with endometriosis in
4.1% (45/1086) of the
cases. Of them, 17 patients (37.8%) had clear cell, 15 (33.3%) had
endometrioid, 6 (13.3%) had serous papillary, 4 (8.9%) had mucinous and
the remaining 3 patients had an undifferentiated subtype of ovarian
carcinoma.
Twenty-three (51.1%) patients had stage I, 4 (8.9%) had stage
II and 18 (40.0%) had stage III disease. The frequency of coexistence
of endometriosis was 20.4% (17/83) for clear cell carcinoma and 9.3%
(15/161) for endometrioid cell carcinoma.
CONCLUSIONS:
Only
a small proportion of ovarian cancer cases were found to be associated
with endometriosis. Endometriosis was most frequently associated with
clear cell and endometrioid types of ovarian carcinoma. Ovarian
carcinoma associated with endometriosis seems to represent a distinct
disease entity with different histological subtypes,
early presentation
and a relatively favorable outcome.
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