abstract
Brain
metastasis is an uncommon but increasing manifestation of ovarian
epithelial carcinoma and neuropathologists' collective experience with
these tumors is limited. We present clinicopathological characteristics
of 13 cases of brain metastases from ovarian epithelial carcinoma
diagnosed at two academic institutions. The mean ages at diagnosis of
the ovarian carcinoma and their subsequent brain metastases were 58.7
and 62.8 years, respectively. At the time of initial diagnosis of
ovarian carcinoma the majority of patients had an advanced stage and
none had brain metastases as their first manifestation of malignancy.
Brain metastases tended to be multiple with ring-enhancing features on
neuroimaging. Primary tumors and their brain metastases were all
high-grade histologically and the histologic subtypes were: nine
high-grade serous carcinoma (HGSC) cases, two clear cell carcinoma (CCC)
cases and a single case each of carcinosarcoma and high-grade
adenocarcinoma. A recommended histo- and immunopathological approach to
these tumours are provided to aid neuropathologists in the recognition
and classification of metastatic ovarian carcinoma to the brain.
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