abstract
Edmonston
vaccine strains of measles virus (MV) have significant antitumor
activity in mouse xenograft models of ovarian cancer (OvCa). MV
engineered to express the sodium iodide symporter gene (MV-NIS)
facilitates localization of viral gene expression and offers a tool for
tumor radiovirotherapy......
.....Here we report results from a clinical
evaluation of MV-NIS delivery in patients with taxol and platinum
resistant OvCa. MV-NIS was given intraperitoneally every 4 wk for up to 6
cycles. ........... Our findings support further clinical
evaluation of MV-NIS as an effective viral immunotherapy.
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