Journal of Ovarian Research | Full text | A targeted analysis identifies a high frequency of BRCA1 and BRCA2 mutation carriers in women with ovarian cancer from a founder population
Background
The frequency of BRCA1 and BRCA2 mutations in ovarian cancer patients varies depending
on histological subtype and population investigated. The six most commonly recurring
BRCA1 and BRCA2 mutations previously identified in a founder French Canadian population
were investigated in 439 histologically defined ovarian, fallopian tube and primary
peritoneal cancer cases that were ascertained at one hospital servicing French Canadians.
To further assess the frequency of BRCA1/BRCA2 mutations, a defined subgroup of 116
cases were investigated for all mutations previously reported in this population.....
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