ScienceDaily
Successful ovarian cancer treatment often relies on catching it early. A
study at The University of Texas MD Anderson Cancer Center may help
point to a new method for women at risk.....
.....The study looked at antibodies produced by patients against the tumor
gene TP53 which is mutated and overexpressed in the majority of ovarian
cancers to see whether their presence would improve the ability of
CA125 to detect ovarian cancer in an earlier stage.
"Anti-TP53 autoantibodies were detected an average of 13 months prior
to rising CA125 levels and 33 months prior to diagnosis in patients who
did not have a rising CA125," said Bast. "While only a quarter of cases
are associated with anti-TP53 autoantibodies, when present, these
antibodies promise to detect ovarian cancer at an earlier interval than
CA125.". The data was presented on April 20 at the 2015 American Association for Cancer Research (AACR) Annual Meeting in Philadelphia.
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