Tabstract
Type 2 diabetes mellitus (T2DM), a chronic disease increasing rapidly
worldwide, is well established as an important risk factor for various
types of cancer. Although many factors impact the development of T2DM
and cancer including sex, age, ethnicity, obesity, diet, physical
activity levels, and environmental exposure, many epidemiological and
experimental studies are gradually contributing to knowledge regarding
the interrelationship between DM and cancer. The insulin resistance,
hyperinsulinemia, and chronic inflammation associated with diabetes
mellitus are all associated strongly with cancer. The changes in
bioavailable ovarian steroid hormone that occur in diabetes mellitus
(the increasing levels of estrogen and androgen and the decreasing level
of progesterone) are also considered potentially carcinogenic
conditions for the breast, endometrium, and ovaries in women. In
addition, the interaction among insulin, insulin-like growth factors
(IGFs), and ovarian steroid hormones, such as estrogen and progesterone,
could act synergistically during cancer development. Here, we review
the cancer-related mechanisms in T2DM, the epidemiological evidence
linking T2DM and cancers in women, and the role of antidiabetic
medication in these cancers.
An ovarian cancer blog which includes quality resource materials: education, research, social networking, genetics and (some) healthcare politics.
“Not everything that can be counted counts and not everything that counts can be counted.”
Albert Einstein
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