Impact of Age at Primary Breast Cancer on Contralateral Breast Cancer Risk in BRCA1/2 Mutation Carriers

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 Conclusion Age at first breast cancer is a strong risk factor for cumulative CBC risk in BRCA1/2 mutation carriers. Considering the available evidence, age-specific risk estimates should be included in counseling......

 In our unselected cohort of patients with breast cancer , we found 10-year cumulative CBC risks of 21.1% for BRCA1 mutation carriers and 10.8% for BRCA2 mutation carriers, which were two to three times higher than for noncarriers (HR, 3.31 for BRCA1; and HR, 2.17 for BRCA2 mutation carriers).