Somatic Mosaic Mutations in PPM1D and TP53 in the Blood of Women With Ovarian Carcinoma

abstract

 In contrast, somatic mosaic mutations in TP53 were not significantly associated with chemotherapy or age.

Conclusions and Relevance  Chemotherapy exposure and age influence the accumulation of PPM1D-mutated PBMC (peripheral blood mononuclear cells) clones. Care should be taken to control for chemotherapy exposure and age at blood draw when testing the association of somatic mosaic mutations in PBMCs with cancer risk.