Immune cells help reverse chemotherapy resistance in ovarian cancer

Science news

 "In the past, we've thought the resistance was caused by genetic changes in tumor cells. But we found that's not the whole story," she says.

 This approach requires additional clinical testing and is not currently available to patients.

Journal Reference:

1. Weimin Wang, Ilona Kryczek, Lubomír Dostál, Heng Lin, Lijun Tan, Lili Zhao, Fujia Lu, Shuang Wei, Tomasz Maj, Dongjun Peng, Gong He, Linda Vatan, Wojciech Szeliga, Rork Kuick, Jan Kotarski, Rafał Tarkowski, Yali Dou, Ramandeep Rattan, Adnan Munkarah, J. Rebecca Liu, Weiping Zou. Effector T Cells Abrogate Stroma-Mediated Chemoresistance in Ovarian Cancer. Cell, 2016; 165 (5): 1092 DOI: 10.1016/j.cell.2016.04.009