abstract
Methodological limitations in studying the association between the use
of fertility drugs and cancer include the inherent increased risk of
cancer in women who never conceive, the low incidence of most of these
cancers, and that the age of diagnosis of cancer typically is many years
after fertility drug use. Based on available data, there does not
appear to be a meaningful increased risk of invasive ovarian cancer,
breast cancer, or endometrial cancer following the use of fertility
drugs. Several studies have shown a small increased risk of borderline
ovarian tumors; however, there is insufficient consistent evidence that a
particular fertility drug increases the risk of borderline ovarian
tumors, and any absolute risk is small. Given the available literature,
patients should be counseled that infertile women may be at an increased
risk of invasive ovarian, endometrial, and breast cancer; however, use
of fertility drugs does not appear to increase this risk.
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