Somatic mutation profiles in primary colorectal cancers and matching ovarian metastases: Identification of driver and passenger mutations

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Somatic mutation profiles in primary colorectal cancers and matching ovarian metastases: Identification of driver and passenger mutations

• Abstract
• Introduction
• Materials and methods
• Results
• Discussion and Conclusion
• Acknowledgements
• Author contributions

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• Supporting Information
• References
• Related Content

 However, in up to 38% of cases, ovarian metastasis detection may precede the detection of the primary CRC [9–11]. In such cases, it is important for treatment
strategies to recognize that the ovarian tumour is a metastasis and not a primary ovarian tumour. Extensive genomic profiling of CRCs and primary ovarian tumours has revealed a limited number of genes helpful in discriminating between these malignancies [12].

 CRCs metastasizing to the ovaries did not show a
specific mutation profile in comparison to consecutive
series of CRC, nor did the ovarian metastases.