OA: Response to the letter of Fagotti et al. regarding the manuscript: “Pattern of and reason for postoperative residual disease in patients with advanced ovarian cancer following upfront radical debulking surgery” Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Monday, November 14, 2016

OA: Response to the letter of Fagotti et al. regarding the manuscript: “Pattern of and reason for postoperative residual disease in patients with advanced ovarian cancer following upfront radical debulking surgery”



open access:
Response to the letter of Fagotti et al. regarding the manuscript: “Pattern of and reason for postoperative residual disease in patients with advanced ovarian cancer following upfront radical debulking surgery”


We thank Fagotti et al. for their interest in our paper describing the patterns and sites.
of residual disease (RD) in patients with advanced ovarian cancer who have undergone primary debulking surgery (PDS) (Heitz et al., 2016) in an expert referral center.....
Not a single chemotherapy trial would ever have been accepted if the dose intensity or protocol completion rate achieved had been at such low ranges similar to the low complete resection rates described in the NACT-IDS trials.
In any case, the fate of a patient should not depend on through which door she enters – Rome or Essen or elsewhere. Rather robust quality improvement criteria and strategies should be implemented in all centers performing this kind of treatments. Fagotti et al. have their merits by assessing the value of laparoscopy in this setting, our focus lies rather on other areas but nevertheless each of us has a small piece to contribute to the bigger picture.
 References
    • Ataseven et al., 2016a
    • Prognostic Impact of Port-Site Metastasis After Diagnostic Laparoscopy for Epithelial Ovarian Cancer
    • Ann. Surg. Oncol., 12 (2016) (Jul,PubMed PMID: 27406097)
    • Ataseven et al., 2016b
    • Impact of Abdominal Wall Metastases on Prognosis in Epithelial Ovarian Cancer
    • Int. J. Gynecol. Cancer (2016) (Sep 19. PubMed PMID: 27654263)
    • Fagotti et al., 2016
    • Phase III randomised clinical trial comparing primary surgery versus neoadjuvant chemotherapy in advanced epithelial ovarian cancer with high tumour load (SCORPION trial): Final analysis of peri-operative outcome
    • Eur. J. Cancer, 59 (2016), pp. 22–33 (PubMed PMID: 26998845, May)
    • | |
    • Harter et al., 2011
    • Impact of a structured quality management program on surgical outcome in primary advanced ovarian cancer
    • Gynecol. Oncol. (2011) (Mar 16. PubMed PMID: 21414656. Eng.)
    • Heitz et al., 2016
    • Pattern of and reason for postoperative residual disease in patients with advanced ovarian cancer following upfront radical debulking surgery
    • Gynecol. Oncol. (2016) (Mar 24. PubMed PMID: 26975900)
    • Vergote et al., 2010
    • Neoadjuvant chemotherapy or primary surgery in stage IIIC or IV ovarian cancer
    • N. Engl. J. Med., 363 (10) (2010), pp. 943–953 (PubMed PMID: 20818904. eng. Sep 2)

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