Journal of Clinical Oncology
The
addition of seribantumab to paclitaxel
did not result in improved PFS
in unselected patients. Exploratory analyses suggest that detectable HRG
and low HER2, biomarkers that link directly to the mechanism of action
of seribantumab, identified patients who might benefit from this
combination. Future clinical trials are needed to validate this finding
and should preselect for HRG expression and focus on cancers with low
HER2 levels.
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