OA: Survival and Control Prognosticators of Recurrent Gynecological Malignancies of the Pelvis and Para-aortic Region Treated with Stereotactic Body Radiation Therapy

open access: Survival and Control Prognosticators of Recurrent Gynecological Malignancies of the Pelvis and Para-aortic Region Treated with Stereotactic Body Radiation Therapy | Radiation Oncology
 

The 2-year LC rate of cervical, endometrioid uterine, and ovarian/non-endometrioid uterine recurrences was 100, 82, and 33, respectively.

Conclusion

Although limited by a small patient population and the intrinsic selection bias of a retrospective review, our data corroborates the promising survival and control rates of pelvic and PA gynecologic recurrences treated by SBRT. The toxicity profile is low especially with PSW and PAN recurrence; however, caution should be used with bigger centrally recurring tumors as they are in close proximity to the rectum/bladder, increasing the risk for fistulas in particular if the target region received previous radiation. Retrospective series such as this one suggest that SBRT is emerging as the salvage therapy of choice for select recurrent gynecologic malignancies in the pelvis and PA region when brachytherapy is not possible. Prospective trials would help determine ideal patient selection to maximize efficacy and limit toxicity.